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Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation
We present a robot that enables high-content studies of alert adult Drosophila by combining operations including gentle picking, translations and rotations, characterizations of fly phenotypes and behaviors, micro-dissection or release. To illustrate, we assessed fly morphology, tracked odor-evoked...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490062/ https://www.ncbi.nlm.nih.gov/pubmed/26005812 http://dx.doi.org/10.1038/nmeth.3410 |
| Sumario: | We present a robot that enables high-content studies of alert adult Drosophila by combining operations including gentle picking, translations and rotations, characterizations of fly phenotypes and behaviors, micro-dissection or release. To illustrate, we assessed fly morphology, tracked odor-evoked locomotion, sorted flies by sex, and dissected the cuticle to image neural activity. The robot's tireless capacity for precise manipulations enables a scalable platform for screening flies’ complex attributes and behavioral patterns. |
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