Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation

We present a robot that enables high-content studies of alert adult Drosophila by combining operations including gentle picking, translations and rotations, characterizations of fly phenotypes and behaviors, micro-dissection or release. To illustrate, we assessed fly morphology, tracked odor-evoked...

Descripción completa

Detalles Bibliográficos
Autores principales: Savall, Joan, Ho, Eric Tatt Wei, Huang, Cheng, Maxey, Jessica R., Schnitzer, Mark J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490062/
https://www.ncbi.nlm.nih.gov/pubmed/26005812
http://dx.doi.org/10.1038/nmeth.3410
_version_ 1782379454648025088
author Savall, Joan
Ho, Eric Tatt Wei
Huang, Cheng
Maxey, Jessica R.
Schnitzer, Mark J.
author_facet Savall, Joan
Ho, Eric Tatt Wei
Huang, Cheng
Maxey, Jessica R.
Schnitzer, Mark J.
author_sort Savall, Joan
collection PubMed
description We present a robot that enables high-content studies of alert adult Drosophila by combining operations including gentle picking, translations and rotations, characterizations of fly phenotypes and behaviors, micro-dissection or release. To illustrate, we assessed fly morphology, tracked odor-evoked locomotion, sorted flies by sex, and dissected the cuticle to image neural activity. The robot's tireless capacity for precise manipulations enables a scalable platform for screening flies’ complex attributes and behavioral patterns.
format Online
Article
Text
id pubmed-4490062
institution National Center for Biotechnology Information
language English
publishDate 2015
record_format MEDLINE/PubMed
spelling pubmed-44900622016-01-01 Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation Savall, Joan Ho, Eric Tatt Wei Huang, Cheng Maxey, Jessica R. Schnitzer, Mark J. Nat Methods Article We present a robot that enables high-content studies of alert adult Drosophila by combining operations including gentle picking, translations and rotations, characterizations of fly phenotypes and behaviors, micro-dissection or release. To illustrate, we assessed fly morphology, tracked odor-evoked locomotion, sorted flies by sex, and dissected the cuticle to image neural activity. The robot's tireless capacity for precise manipulations enables a scalable platform for screening flies’ complex attributes and behavioral patterns. 2015-05-25 2015-07 /pmc/articles/PMC4490062/ /pubmed/26005812 http://dx.doi.org/10.1038/nmeth.3410 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Savall, Joan
Ho, Eric Tatt Wei
Huang, Cheng
Maxey, Jessica R.
Schnitzer, Mark J.
Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation
title Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation
title_full Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation
title_fullStr Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation
title_full_unstemmed Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation
title_short Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation
title_sort dexterous robotic manipulation of alert adult drosophila for high-content experimentation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490062/
https://www.ncbi.nlm.nih.gov/pubmed/26005812
http://dx.doi.org/10.1038/nmeth.3410
work_keys_str_mv AT savalljoan dexterousroboticmanipulationofalertadultdrosophilaforhighcontentexperimentation
AT hoerictattwei dexterousroboticmanipulationofalertadultdrosophilaforhighcontentexperimentation
AT huangcheng dexterousroboticmanipulationofalertadultdrosophilaforhighcontentexperimentation
AT maxeyjessicar dexterousroboticmanipulationofalertadultdrosophilaforhighcontentexperimentation
AT schnitzermarkj dexterousroboticmanipulationofalertadultdrosophilaforhighcontentexperimentation

Ejemplares similares