Cargando…

Centromere pairing – tethering partner chromosomes in meiosis I

In meiosis, homologous chromosomes face the obstacle of finding, holding onto and segregating away from their partner chromosome. There is increasing evidence, in a diverse range of organisms, that centromere–centromere interactions that occur in late prophase are an important mechanism in ensuring...

Descripción completa

Detalles Bibliográficos
Autores principales: Kurdzo, Emily L, Dawson, Dean S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490064/
https://www.ncbi.nlm.nih.gov/pubmed/25817724
http://dx.doi.org/10.1111/febs.13280
_version_ 1782379455090524160
author Kurdzo, Emily L
Dawson, Dean S
author_facet Kurdzo, Emily L
Dawson, Dean S
author_sort Kurdzo, Emily L
collection PubMed
description In meiosis, homologous chromosomes face the obstacle of finding, holding onto and segregating away from their partner chromosome. There is increasing evidence, in a diverse range of organisms, that centromere–centromere interactions that occur in late prophase are an important mechanism in ensuring segregation fidelity. Centromere pairing appears to initiate when homologous chromosomes synapse in meiotic prophase. Structural proteins of the synaptonemal complex have been shown to help mediate centromere pairing, but how the structure that maintains centromere pairing differs from the structure of the synaptonemal complex along the chromosomal arms remains unknown. When the synaptonemal complex proteins disassemble from the chromosome arms in late prophase, some of these synaptonemal complex components persist at the centromeres. In yeast and Drosophila these centromere-pairing behaviors promote the proper segregation of chromosome partners that have failed to become linked by chiasmata. Recent studies of mouse spermatocytes have described centromere pairing behaviors that are similar in several respects to what has been described in the fly and yeast systems. In humans, chromosomes that fail to experience crossovers in meiosis are error-prone and are a major source of aneuploidy. The finding that centromere pairing is a conserved phenomenon raises the possibility that it may play a role in promoting the segregation fidelity of non-exchange chromosome pairs in humans.
format Online
Article
Text
id pubmed-4490064
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher John Wiley & Sons, Ltd
record_format MEDLINE/PubMed
spelling pubmed-44900642015-07-03 Centromere pairing – tethering partner chromosomes in meiosis I Kurdzo, Emily L Dawson, Dean S FEBS J Minireview In meiosis, homologous chromosomes face the obstacle of finding, holding onto and segregating away from their partner chromosome. There is increasing evidence, in a diverse range of organisms, that centromere–centromere interactions that occur in late prophase are an important mechanism in ensuring segregation fidelity. Centromere pairing appears to initiate when homologous chromosomes synapse in meiotic prophase. Structural proteins of the synaptonemal complex have been shown to help mediate centromere pairing, but how the structure that maintains centromere pairing differs from the structure of the synaptonemal complex along the chromosomal arms remains unknown. When the synaptonemal complex proteins disassemble from the chromosome arms in late prophase, some of these synaptonemal complex components persist at the centromeres. In yeast and Drosophila these centromere-pairing behaviors promote the proper segregation of chromosome partners that have failed to become linked by chiasmata. Recent studies of mouse spermatocytes have described centromere pairing behaviors that are similar in several respects to what has been described in the fly and yeast systems. In humans, chromosomes that fail to experience crossovers in meiosis are error-prone and are a major source of aneuploidy. The finding that centromere pairing is a conserved phenomenon raises the possibility that it may play a role in promoting the segregation fidelity of non-exchange chromosome pairs in humans. John Wiley & Sons, Ltd 2015-07 2015-04-13 /pmc/articles/PMC4490064/ /pubmed/25817724 http://dx.doi.org/10.1111/febs.13280 Text en © 2015 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Minireview
Kurdzo, Emily L
Dawson, Dean S
Centromere pairing – tethering partner chromosomes in meiosis I
title Centromere pairing – tethering partner chromosomes in meiosis I
title_full Centromere pairing – tethering partner chromosomes in meiosis I
title_fullStr Centromere pairing – tethering partner chromosomes in meiosis I
title_full_unstemmed Centromere pairing – tethering partner chromosomes in meiosis I
title_short Centromere pairing – tethering partner chromosomes in meiosis I
title_sort centromere pairing – tethering partner chromosomes in meiosis i
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490064/
https://www.ncbi.nlm.nih.gov/pubmed/25817724
http://dx.doi.org/10.1111/febs.13280
work_keys_str_mv AT kurdzoemilyl centromerepairingtetheringpartnerchromosomesinmeiosisi
AT dawsondeans centromerepairingtetheringpartnerchromosomesinmeiosisi