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A comparison of ultrasound and magnetic resonance imaging shows kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease
ADPKD is marked by gradual renal cyst and kidney enlargement and ultimately renal failure. Magnetic resonance-based, height-adjusted total kidney volume (htTKV) over 600 ml/m predicts the development of CKD Stage 3 within 8 years in the Consortium for Radiologic Imaging in Polycystic Kidney Disease...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490113/ https://www.ncbi.nlm.nih.gov/pubmed/25830764 http://dx.doi.org/10.1038/ki.2015.71 |
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author | Bhutani, Harpreet Smith, Vikram Rahbari-Oskoui, Frederic Mittal, Ankush Grantham, Jared J Torres, Vicente E. Mrug, Michal Bae, Kyongtae T. Wu, Zhiyuan Ge, Yinghui Landslittel, Doug Gibbs, Patrice O’Neill, W Charles Chapman, Arlene B. |
author_facet | Bhutani, Harpreet Smith, Vikram Rahbari-Oskoui, Frederic Mittal, Ankush Grantham, Jared J Torres, Vicente E. Mrug, Michal Bae, Kyongtae T. Wu, Zhiyuan Ge, Yinghui Landslittel, Doug Gibbs, Patrice O’Neill, W Charles Chapman, Arlene B. |
author_sort | Bhutani, Harpreet |
collection | PubMed |
description | ADPKD is marked by gradual renal cyst and kidney enlargement and ultimately renal failure. Magnetic resonance-based, height-adjusted total kidney volume (htTKV) over 600 ml/m predicts the development of CKD Stage 3 within 8 years in the Consortium for Radiologic Imaging in Polycystic Kidney Disease cohort. Here we compared simultaneous ultrasound and magnetic resonance imaging to determine if ultrasound and kidney length (KL) predict future CKD Stage 3 over longer periods of follow-up. A total of 241 ADPKD patients, 15–46 years, with creatinine clearance of 70 ml/min and above had iothalamate clearance, magnetic resonance and ultrasound evaluations. Participants underwent an average of five repeat clearance measurements over a mean follow-up of 9.3 years. Ultrasound and magnetic resonance-based TKV and KL were compared using Bland-Altman plots and intra-class correlations. Each measure was tested to predict future CKD Stage 3. Relatively strong intra-class correlations between ultrasound and magnetic resonance were found for both htTKV and KL (0.81 and 0.85, respectively). Ultrasound and magnetic resonance-based htTKV and KL predicted future CKD Stage 3 similarly (AUC of 0.87, 0.88, 0.87 and 0.88 respectively). An ultrasound kidney length over 16.5 cm and htTKV over 650 ml/m had the best cut-point for predicting the development of CKD Stage 3. Thus, kidney length alone is sufficient to stratify the risk of progression to renal insufficiency early in ADPKD using either ultrasound or magnetic resonance imaging. |
format | Online Article Text |
id | pubmed-4490113 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-44901132016-01-01 A comparison of ultrasound and magnetic resonance imaging shows kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease Bhutani, Harpreet Smith, Vikram Rahbari-Oskoui, Frederic Mittal, Ankush Grantham, Jared J Torres, Vicente E. Mrug, Michal Bae, Kyongtae T. Wu, Zhiyuan Ge, Yinghui Landslittel, Doug Gibbs, Patrice O’Neill, W Charles Chapman, Arlene B. Kidney Int Article ADPKD is marked by gradual renal cyst and kidney enlargement and ultimately renal failure. Magnetic resonance-based, height-adjusted total kidney volume (htTKV) over 600 ml/m predicts the development of CKD Stage 3 within 8 years in the Consortium for Radiologic Imaging in Polycystic Kidney Disease cohort. Here we compared simultaneous ultrasound and magnetic resonance imaging to determine if ultrasound and kidney length (KL) predict future CKD Stage 3 over longer periods of follow-up. A total of 241 ADPKD patients, 15–46 years, with creatinine clearance of 70 ml/min and above had iothalamate clearance, magnetic resonance and ultrasound evaluations. Participants underwent an average of five repeat clearance measurements over a mean follow-up of 9.3 years. Ultrasound and magnetic resonance-based TKV and KL were compared using Bland-Altman plots and intra-class correlations. Each measure was tested to predict future CKD Stage 3. Relatively strong intra-class correlations between ultrasound and magnetic resonance were found for both htTKV and KL (0.81 and 0.85, respectively). Ultrasound and magnetic resonance-based htTKV and KL predicted future CKD Stage 3 similarly (AUC of 0.87, 0.88, 0.87 and 0.88 respectively). An ultrasound kidney length over 16.5 cm and htTKV over 650 ml/m had the best cut-point for predicting the development of CKD Stage 3. Thus, kidney length alone is sufficient to stratify the risk of progression to renal insufficiency early in ADPKD using either ultrasound or magnetic resonance imaging. 2015-04-01 2015-07 /pmc/articles/PMC4490113/ /pubmed/25830764 http://dx.doi.org/10.1038/ki.2015.71 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Bhutani, Harpreet Smith, Vikram Rahbari-Oskoui, Frederic Mittal, Ankush Grantham, Jared J Torres, Vicente E. Mrug, Michal Bae, Kyongtae T. Wu, Zhiyuan Ge, Yinghui Landslittel, Doug Gibbs, Patrice O’Neill, W Charles Chapman, Arlene B. A comparison of ultrasound and magnetic resonance imaging shows kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease |
title | A comparison of ultrasound and magnetic resonance imaging shows kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease |
title_full | A comparison of ultrasound and magnetic resonance imaging shows kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease |
title_fullStr | A comparison of ultrasound and magnetic resonance imaging shows kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease |
title_full_unstemmed | A comparison of ultrasound and magnetic resonance imaging shows kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease |
title_short | A comparison of ultrasound and magnetic resonance imaging shows kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease |
title_sort | comparison of ultrasound and magnetic resonance imaging shows kidney length predicts chronic kidney disease in autosomal dominant polycystic kidney disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490113/ https://www.ncbi.nlm.nih.gov/pubmed/25830764 http://dx.doi.org/10.1038/ki.2015.71 |
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