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Longevity factor klotho and chronic psychological stress
Chronic psychological stress is associated with accelerated aging and premature morbidity and mortality; however, the biology linking chronic psychological stress and its maladaptive effects remains largely unknown. Klotho is a pleiotropic hormone that regulates the aging process and promotes better...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490291/ https://www.ncbi.nlm.nih.gov/pubmed/26080320 http://dx.doi.org/10.1038/tp.2015.81 |
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author | Prather, A A Epel, E S Arenander, J Broestl, L Garay, B I Wang, D Dubal, D B |
author_facet | Prather, A A Epel, E S Arenander, J Broestl, L Garay, B I Wang, D Dubal, D B |
author_sort | Prather, A A |
collection | PubMed |
description | Chronic psychological stress is associated with accelerated aging and premature morbidity and mortality; however, the biology linking chronic psychological stress and its maladaptive effects remains largely unknown. Klotho is a pleiotropic hormone that regulates the aging process and promotes better brain and body health. Whether klotho is linked to psychosocial stress or its negative impact in humans has not been investigated. To address this gap, we recruited 178 healthy women who were either chronically high-stress maternal caregivers for a child with autism spectrum disorder (n=90) or low-stress control mothers of a typically developing child (n=88). We found that women under high chronic stress displayed significantly lower levels of the longevity hormone klotho compared with low-stress controls (t(176)=2.92, P=0.004; d=0.44), and the decrease among those under high stress was age-dependent. In addition, high-stress caregivers who reported more depressive symptoms displayed even lower klotho levels compared with low-stress participants. These findings provide the first evidence that klotho levels are sensitive to psychosocial stressors and raise the possibility that klotho may serve as a novel biological link connecting stress, depression and risk for accelerated disease development. Furthermore, these findings have important implications for understanding the plasticity of the aging process and may represent a therapeutic target for mitigating the deleterious effects of chronic psychological stress on health and well-being. |
format | Online Article Text |
id | pubmed-4490291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44902912015-07-13 Longevity factor klotho and chronic psychological stress Prather, A A Epel, E S Arenander, J Broestl, L Garay, B I Wang, D Dubal, D B Transl Psychiatry Original Article Chronic psychological stress is associated with accelerated aging and premature morbidity and mortality; however, the biology linking chronic psychological stress and its maladaptive effects remains largely unknown. Klotho is a pleiotropic hormone that regulates the aging process and promotes better brain and body health. Whether klotho is linked to psychosocial stress or its negative impact in humans has not been investigated. To address this gap, we recruited 178 healthy women who were either chronically high-stress maternal caregivers for a child with autism spectrum disorder (n=90) or low-stress control mothers of a typically developing child (n=88). We found that women under high chronic stress displayed significantly lower levels of the longevity hormone klotho compared with low-stress controls (t(176)=2.92, P=0.004; d=0.44), and the decrease among those under high stress was age-dependent. In addition, high-stress caregivers who reported more depressive symptoms displayed even lower klotho levels compared with low-stress participants. These findings provide the first evidence that klotho levels are sensitive to psychosocial stressors and raise the possibility that klotho may serve as a novel biological link connecting stress, depression and risk for accelerated disease development. Furthermore, these findings have important implications for understanding the plasticity of the aging process and may represent a therapeutic target for mitigating the deleterious effects of chronic psychological stress on health and well-being. Nature Publishing Group 2015-06 2015-06-16 /pmc/articles/PMC4490291/ /pubmed/26080320 http://dx.doi.org/10.1038/tp.2015.81 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Original Article Prather, A A Epel, E S Arenander, J Broestl, L Garay, B I Wang, D Dubal, D B Longevity factor klotho and chronic psychological stress |
title | Longevity factor klotho and chronic psychological stress |
title_full | Longevity factor klotho and chronic psychological stress |
title_fullStr | Longevity factor klotho and chronic psychological stress |
title_full_unstemmed | Longevity factor klotho and chronic psychological stress |
title_short | Longevity factor klotho and chronic psychological stress |
title_sort | longevity factor klotho and chronic psychological stress |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490291/ https://www.ncbi.nlm.nih.gov/pubmed/26080320 http://dx.doi.org/10.1038/tp.2015.81 |
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