The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function

The concept of cognitive reserve (CR) has been proposed to account for observed discrepancies between pathology and its clinical manifestation due to underlying differences in brain structure and function. In 433 healthy older adults participating in the Tasmanian Healthy Brain Project, we investiga...

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Detalles Bibliográficos
Autores principales: Ward, D D, Summers, M J, Saunders, N L, Ritchie, K, Summers, J J, Vickers, J C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490292/
https://www.ncbi.nlm.nih.gov/pubmed/26125153
http://dx.doi.org/10.1038/tp.2015.82
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author Ward, D D
Summers, M J
Saunders, N L
Ritchie, K
Summers, J J
Vickers, J C
author_facet Ward, D D
Summers, M J
Saunders, N L
Ritchie, K
Summers, J J
Vickers, J C
author_sort Ward, D D
collection PubMed
description The concept of cognitive reserve (CR) has been proposed to account for observed discrepancies between pathology and its clinical manifestation due to underlying differences in brain structure and function. In 433 healthy older adults participating in the Tasmanian Healthy Brain Project, we investigated whether common polymorphic variations in apolipoprotein E (APOE) or brain-derived neurotrophic factor (BDNF) influenced the association between CR contributors and cognitive function in older adults. We show that BDNF Val66Met moderates the association between CR and executive function. CR accounted for 8.5% of the variance in executive function in BDNF Val homozygotes, but CR was a nonsignificant predictor in BDNF Met carriers. APOE polymorphisms were not linked to the influence of CR on cognitive function. This result implicates BDNF in having an important role in capacity for building or accessing CR.
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spelling pubmed-44902922015-07-13 The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function Ward, D D Summers, M J Saunders, N L Ritchie, K Summers, J J Vickers, J C Transl Psychiatry Original Article The concept of cognitive reserve (CR) has been proposed to account for observed discrepancies between pathology and its clinical manifestation due to underlying differences in brain structure and function. In 433 healthy older adults participating in the Tasmanian Healthy Brain Project, we investigated whether common polymorphic variations in apolipoprotein E (APOE) or brain-derived neurotrophic factor (BDNF) influenced the association between CR contributors and cognitive function in older adults. We show that BDNF Val66Met moderates the association between CR and executive function. CR accounted for 8.5% of the variance in executive function in BDNF Val homozygotes, but CR was a nonsignificant predictor in BDNF Met carriers. APOE polymorphisms were not linked to the influence of CR on cognitive function. This result implicates BDNF in having an important role in capacity for building or accessing CR. Nature Publishing Group 2015-06 2015-06-30 /pmc/articles/PMC4490292/ /pubmed/26125153 http://dx.doi.org/10.1038/tp.2015.82 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Original Article
Ward, D D
Summers, M J
Saunders, N L
Ritchie, K
Summers, J J
Vickers, J C
The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function
title The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function
title_full The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function
title_fullStr The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function
title_full_unstemmed The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function
title_short The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function
title_sort bdnf val66met polymorphism moderates the relationship between cognitive reserve and executive function
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490292/
https://www.ncbi.nlm.nih.gov/pubmed/26125153
http://dx.doi.org/10.1038/tp.2015.82
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