Cargando…

Major depressive disorder and current psychological distress moderate the effect of polygenic risk for obesity on body mass index

Major depressive disorder (MDD) and obesity are frequently co-morbid and this correlation is partly due to genetic factors. Although specific genetic risk variants are associated with body mass index (BMI) and with larger effect sizes in depressed individuals, the genetic overlap and interaction wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Clarke, T-K, Hall, L S, Fernandez-Pujals, A M, MacIntyre, D J, Thomson, P, Hayward, C, Smith, B H, Padmanabhan, S, Hocking, L J, Deary, I J, Porteous, D J, McIntosh, A M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490293/ https://www.ncbi.nlm.nih.gov/pubmed/26125155 http://dx.doi.org/10.1038/tp.2015.83

Ejemplares similares

Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population‐based cohort
por: Clarke, Toni‐Kim, et al.
Publicado: (2015)

Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population
por: Clarke, T-K, et al.
Publicado: (2016)

A Combined Pathway and Regional Heritability Analysis Indicates NETRIN1 Pathway Is Associated With Major Depressive Disorder
por: Zeng, Yanni, et al.
Publicado: (2017)

Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts
por: Whalley, H C, et al.
Publicado: (2016)

Polygenic risk for coronary artery disease is associated with cognitive ability in older adults
por: Hagenaars, Saskia P, et al.
Publicado: (2016)

Investigating shared aetiology between type 2 diabetes and major depressive disorder in a population based cohort
por: Clarke, Toni‐Kim, et al.
Publicado: (2016)

Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n=19 762), UK Biobank (n=24 048) and the English Longitudinal Study of Ageing (n=5766)
por: Wigmore, E M, et al.
Publicado: (2017)

Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression
por: Zeng, Yanni, et al.
Publicado: (2016)

Assessing the presence of shared genetic architecture between Alzheimer's disease and major depressive disorder using genome-wide association data
por: Gibson, J, et al.
Publicado: (2017)

Intelligence and neuroticism in relation to depression and psychological distress: Evidence from two large population cohorts
por: Navrady, L.B., et al.
Publicado: (2017)

Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)
por: Clarke, T-K, et al.
Publicado: (2017)

Epidemiology and Heritability of Major Depressive Disorder, Stratified by Age of Onset, Sex, and Illness Course in Generation Scotland: Scottish Family Health Study (GS:SFHS)
por: Fernandez-Pujals, Ana Maria, et al.
Publicado: (2015)

Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression
por: McIntosh, Andrew M., et al.
Publicado: (2012)

Psychological distress, neuroticism, and cause-specific mortality: early prospective evidence from UK Biobank
por: Batty, G David, et al.
Publicado: (2016)

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
por: Shen, Xueyi, et al.
Publicado: (2020)

Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank
por: Reus, L. M., et al.
Publicado: (2017)

Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism
por: Clarke, Toni-Kim, et al.
Publicado: (2019)

Cohort Profile: Stratifying Resilience and Depression Longitudinally (STRADL): a questionnaire follow-up of Generation Scotland: Scottish Family Health Study (GS:SFHS)
por: Navrady, L B, et al.
Publicado: (2018)

Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis
por: McIntosh, Andrew M., et al.
Publicado: (2016)

Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank
por: Howard, David M., et al.
Publicado: (2017)

Polygenic risk of ischemic stroke is associated with cognitive ability
por: Harris, Sarah E., et al.
Publicado: (2016)

Genetic risk of major depressive disorder: the moderating and mediating effects of neuroticism and psychological resilience on clinical and self-reported depression
por: Navrady, L. B., et al.
Publicado: (2018)

A validation of the diathesis-stress model for depression in Generation Scotland
por: Arnau-Soler, Aleix, et al.
Publicado: (2019)

Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population
por: Clarke, Toni-Kim, et al.
Publicado: (2019)

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank
por: Hall, Lynsey S., et al.
Publicado: (2018)

Genetic and environmental contributions to psychological resilience and coping
por: Navrady, Lauren B, et al.
Publicado: (2018)

Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank
por: Barbu, Miruna C., et al.
Publicado: (2019)

Using tree-based methods for detection of gene–gene interactions in the presence of a polygenic signal: simulation study with application to educational attainment in the Generation Scotland Cohort Study
por: Meijsen, Joeri J, et al.
Publicado: (2019)

The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI
por: Whalley, H C, et al.
Publicado: (2012)

Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP
por: Wigmore, Eleanor M., et al.
Publicado: (2019)

Insulin resistance: Genetic associations with depression and cognition in population based cohorts
por: Frangou, Sophia, et al.
Publicado: (2019)

Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland
por: Arnau-Soler, Aleix, et al.
Publicado: (2019)

Common Genetic Variants Explain the Majority of the Correlation Between Height and Intelligence: The Generation Scotland Study
por: Marioni, Riccardo E., et al.
Publicado: (2014)

Life-course pathways to psychological distress: a cohort study
por: von Stumm, Sophie, et al.
Publicado: (2013)

Self-reported medication use validated through record linkage to national prescribing data
por: Hafferty, Jonathan D., et al.
Publicado: (2018)

Reaction time and onset of psychological distress: the UK Health and Lifestyle Survey
por: Gale, Catharine R, et al.
Publicado: (2016)

Genetic contributions to two special factors of neuroticism are associated with affluence, higher intelligence, better health, and longer life
por: Hill, W. David, et al.
Publicado: (2019)

A polygenic resilience score moderates the genetic risk for schizophrenia
por: Hess, Jonathan L., et al.
Publicado: (2019)

Epigenetic prediction of major depressive disorder
por: Barbu, Miruna C., et al.
Publicado: (2020)

Factors associated with sharing e-mail information and mental health survey participation in large population cohorts
por: Adams, Mark J, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_am7t495i7i8a0p8i1i1hlj61sm