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Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study
PURPOSE: In this study, we compared the treatment outcomes for an α-blocker between 2 groups of men, one with high sympathetic activity (HSA) and another with low sympathetic activity (LSA) or normal sympathetic activity. METHODS: A total of 159 men (≥50 years of age) with lower urinary tract sympto...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Continence Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490311/ https://www.ncbi.nlm.nih.gov/pubmed/26126440 http://dx.doi.org/10.5213/inj.2015.19.2.107 |
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author | Park, Sung Gon Chung, Byung Ha Lee, Sung Won Park, Jong Kwan Park, Kwangsung Cheon, Jun Lee, Kyung Seop Kim, Hyung-Jee Seong, Do-Hwan Oh, Seung-June Kim, Sae Woong Lee, Ji Youl Choo, Seol Ho Choi, Jong Bo |
author_facet | Park, Sung Gon Chung, Byung Ha Lee, Sung Won Park, Jong Kwan Park, Kwangsung Cheon, Jun Lee, Kyung Seop Kim, Hyung-Jee Seong, Do-Hwan Oh, Seung-June Kim, Sae Woong Lee, Ji Youl Choo, Seol Ho Choi, Jong Bo |
author_sort | Park, Sung Gon |
collection | PubMed |
description | PURPOSE: In this study, we compared the treatment outcomes for an α-blocker between 2 groups of men, one with high sympathetic activity (HSA) and another with low sympathetic activity (LSA) or normal sympathetic activity. METHODS: A total of 159 men (≥50 years of age) with lower urinary tract symptoms resulting from benign prostatic hyperplasia were analyzed. We assigned patients to groups according to their sympathetic activity, which was evaluated by heart ratevariability measurements. HSA was defined as a low frequency/high frequency ratio greater than 1.6. All patients received 10mg of alfuzosin once a day for 12 weeks. The primary end point was a change in the total International Prostate SymptomScore (IPSS) at 12 weeks from baseline. RESULTS: Sixty-seven men were assigned to the HSA group and 92 men were assigned to the LSA group. The baseline characteristics were not significantly different between the 2 groups, and the response to alfuzosin was good in both groups. Themean total IPSS change was not different between the groups. Both groups were not significantly different with respect to the changes in maximal flow rate, IPSS voiding or storage symptom subscores, quality of life, and rates of adverse drug events. TheHSA group showed a similar willingness to continue treatment compared to the LSA group, although their treatment satisfaction rating was lower. CONCLUSIONS: The therapeutic effects of alfuzosin did not differ in regards to the differences in sympathetic activity, but treatment satisfaction ratings were lower in the HSA group. |
format | Online Article Text |
id | pubmed-4490311 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Korean Continence Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-44903112015-07-06 Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study Park, Sung Gon Chung, Byung Ha Lee, Sung Won Park, Jong Kwan Park, Kwangsung Cheon, Jun Lee, Kyung Seop Kim, Hyung-Jee Seong, Do-Hwan Oh, Seung-June Kim, Sae Woong Lee, Ji Youl Choo, Seol Ho Choi, Jong Bo Int Neurourol J Original Article PURPOSE: In this study, we compared the treatment outcomes for an α-blocker between 2 groups of men, one with high sympathetic activity (HSA) and another with low sympathetic activity (LSA) or normal sympathetic activity. METHODS: A total of 159 men (≥50 years of age) with lower urinary tract symptoms resulting from benign prostatic hyperplasia were analyzed. We assigned patients to groups according to their sympathetic activity, which was evaluated by heart ratevariability measurements. HSA was defined as a low frequency/high frequency ratio greater than 1.6. All patients received 10mg of alfuzosin once a day for 12 weeks. The primary end point was a change in the total International Prostate SymptomScore (IPSS) at 12 weeks from baseline. RESULTS: Sixty-seven men were assigned to the HSA group and 92 men were assigned to the LSA group. The baseline characteristics were not significantly different between the 2 groups, and the response to alfuzosin was good in both groups. Themean total IPSS change was not different between the groups. Both groups were not significantly different with respect to the changes in maximal flow rate, IPSS voiding or storage symptom subscores, quality of life, and rates of adverse drug events. TheHSA group showed a similar willingness to continue treatment compared to the LSA group, although their treatment satisfaction rating was lower. CONCLUSIONS: The therapeutic effects of alfuzosin did not differ in regards to the differences in sympathetic activity, but treatment satisfaction ratings were lower in the HSA group. Korean Continence Society 2015-06 2015-06-29 /pmc/articles/PMC4490311/ /pubmed/26126440 http://dx.doi.org/10.5213/inj.2015.19.2.107 Text en Copyright © 2015 Korean Continence Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Sung Gon Chung, Byung Ha Lee, Sung Won Park, Jong Kwan Park, Kwangsung Cheon, Jun Lee, Kyung Seop Kim, Hyung-Jee Seong, Do-Hwan Oh, Seung-June Kim, Sae Woong Lee, Ji Youl Choo, Seol Ho Choi, Jong Bo Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study |
title | Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study |
title_full | Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study |
title_fullStr | Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study |
title_full_unstemmed | Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study |
title_short | Alpha-Blocker Treatment Response in Men With Lower Urinary Tract Symptoms Based on Sympathetic Activity: Prospective, Multicenter, Open-Labeled, Observational Study |
title_sort | alpha-blocker treatment response in men with lower urinary tract symptoms based on sympathetic activity: prospective, multicenter, open-labeled, observational study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490311/ https://www.ncbi.nlm.nih.gov/pubmed/26126440 http://dx.doi.org/10.5213/inj.2015.19.2.107 |
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