High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification

Alzheimer’s disease is characterized by the misfolding and self-assembly of the amyloidogenic protein amyloid-β (Aβ). The aggregation of Aβ leads to diverse oligomeric states, each of which may be potential targets for intervention. Obtaining insight into Aβ oligomers at the atomic level has been a...

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Detalles Bibliográficos
Autores principales: Kotler, Samuel A., Brender, Jeffrey R., Vivekanandan, Subramanian, Suzuki, Yuta, Yamamoto, Kazutoshi, Monette, Martine, Krishnamoorthy, Janarthanan, Walsh, Patrick, Cauble, Meagan, Holl, Mark M. Banaszak, Marsh, E. Neil. G., Ramamoorthy, Ayyalusamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490348/
https://www.ncbi.nlm.nih.gov/pubmed/26138908
http://dx.doi.org/10.1038/srep11811

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