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PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients

The influence of patatin-like phospholipase domain-containing 3 (PNPLA3) genetic variants in the development of liver steatosis in Asian chronic hepatitis C patients remains elusive. A total of 1018 biopsy-proven chronic hepatitis C patients were enrolled for evaluation. The proportions of PNPLA3 rs...

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Detalles Bibliográficos
Autores principales: Huang, Chung-Feng, Chen, Jyh-Jou, Yeh, Ming-Lun, Huang, Ching-I, Hsieh, Ming-Yen, Yang, Hua-Ling, Dai, Chia-Yen, Huang, Jee-Fu, Lin, Zu-Yau, Chen, Shinn-Cherng, Chuang, Wan-Long, Chen, Yao-Li, Yu, Ming-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490397/
https://www.ncbi.nlm.nih.gov/pubmed/26139292
http://dx.doi.org/10.1038/srep11901
Descripción
Sumario:The influence of patatin-like phospholipase domain-containing 3 (PNPLA3) genetic variants in the development of liver steatosis in Asian chronic hepatitis C patients remains elusive. A total of 1018 biopsy-proven chronic hepatitis C patients were enrolled for evaluation. The proportions of PNPLA3 rs738409 GG genotype carriage were 7.8% (44/563), 15.8% (58/367) and 19.3% (17/88) in patients with no (liver fat content <5%), mild (5–33%) and moderate/severe (>66%) hepatic steatosis, respectively (trend P < 0.001). Stepwise logistic regression analysis revealed that the strongest factor independently associated with steatosis was the carriage of the PNPLA3 rs738409 GG genotype (odds ratio [OR]/95% confidence intervals [CI]:2.34/1.557–3.515, P < 0.001). Among the patients with BMI < 24 kg/m(2), carriage of the rs738409 GG genotype was the only factor associated with hepatic steatosis (OR/CI:3.44/1.824–6.500, P < 0.001). PNPLA3 genetic variants had minimal effects on hepatic steatosis among overweight or obese patients. Compared to patients with BMI<24 kg/m(2)/non-GG genotype, those with BMI>24 kg/m(2)/GG genotype were more likely to have hepatic steatosis (OR/CI:3.87/2.292–6.524, P < 0.001). In conclusions, both PNPLA3 genetic variants and BMI played important roles in hepatic steatosis among Asian chronic hepatitis C patients. However, the genetic effect was mainly restricted to non-obese patients.