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PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients

The influence of patatin-like phospholipase domain-containing 3 (PNPLA3) genetic variants in the development of liver steatosis in Asian chronic hepatitis C patients remains elusive. A total of 1018 biopsy-proven chronic hepatitis C patients were enrolled for evaluation. The proportions of PNPLA3 rs...

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Autores principales: Huang, Chung-Feng, Chen, Jyh-Jou, Yeh, Ming-Lun, Huang, Ching-I, Hsieh, Ming-Yen, Yang, Hua-Ling, Dai, Chia-Yen, Huang, Jee-Fu, Lin, Zu-Yau, Chen, Shinn-Cherng, Chuang, Wan-Long, Chen, Yao-Li, Yu, Ming-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490397/
https://www.ncbi.nlm.nih.gov/pubmed/26139292
http://dx.doi.org/10.1038/srep11901
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author Huang, Chung-Feng
Chen, Jyh-Jou
Yeh, Ming-Lun
Huang, Ching-I
Hsieh, Ming-Yen
Yang, Hua-Ling
Dai, Chia-Yen
Huang, Jee-Fu
Lin, Zu-Yau
Chen, Shinn-Cherng
Chuang, Wan-Long
Chen, Yao-Li
Yu, Ming-Lung
author_facet Huang, Chung-Feng
Chen, Jyh-Jou
Yeh, Ming-Lun
Huang, Ching-I
Hsieh, Ming-Yen
Yang, Hua-Ling
Dai, Chia-Yen
Huang, Jee-Fu
Lin, Zu-Yau
Chen, Shinn-Cherng
Chuang, Wan-Long
Chen, Yao-Li
Yu, Ming-Lung
author_sort Huang, Chung-Feng
collection PubMed
description The influence of patatin-like phospholipase domain-containing 3 (PNPLA3) genetic variants in the development of liver steatosis in Asian chronic hepatitis C patients remains elusive. A total of 1018 biopsy-proven chronic hepatitis C patients were enrolled for evaluation. The proportions of PNPLA3 rs738409 GG genotype carriage were 7.8% (44/563), 15.8% (58/367) and 19.3% (17/88) in patients with no (liver fat content <5%), mild (5–33%) and moderate/severe (>66%) hepatic steatosis, respectively (trend P < 0.001). Stepwise logistic regression analysis revealed that the strongest factor independently associated with steatosis was the carriage of the PNPLA3 rs738409 GG genotype (odds ratio [OR]/95% confidence intervals [CI]:2.34/1.557–3.515, P < 0.001). Among the patients with BMI < 24 kg/m(2), carriage of the rs738409 GG genotype was the only factor associated with hepatic steatosis (OR/CI:3.44/1.824–6.500, P < 0.001). PNPLA3 genetic variants had minimal effects on hepatic steatosis among overweight or obese patients. Compared to patients with BMI<24 kg/m(2)/non-GG genotype, those with BMI>24 kg/m(2)/GG genotype were more likely to have hepatic steatosis (OR/CI:3.87/2.292–6.524, P < 0.001). In conclusions, both PNPLA3 genetic variants and BMI played important roles in hepatic steatosis among Asian chronic hepatitis C patients. However, the genetic effect was mainly restricted to non-obese patients.
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spelling pubmed-44903972015-07-07 PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients Huang, Chung-Feng Chen, Jyh-Jou Yeh, Ming-Lun Huang, Ching-I Hsieh, Ming-Yen Yang, Hua-Ling Dai, Chia-Yen Huang, Jee-Fu Lin, Zu-Yau Chen, Shinn-Cherng Chuang, Wan-Long Chen, Yao-Li Yu, Ming-Lung Sci Rep Article The influence of patatin-like phospholipase domain-containing 3 (PNPLA3) genetic variants in the development of liver steatosis in Asian chronic hepatitis C patients remains elusive. A total of 1018 biopsy-proven chronic hepatitis C patients were enrolled for evaluation. The proportions of PNPLA3 rs738409 GG genotype carriage were 7.8% (44/563), 15.8% (58/367) and 19.3% (17/88) in patients with no (liver fat content <5%), mild (5–33%) and moderate/severe (>66%) hepatic steatosis, respectively (trend P < 0.001). Stepwise logistic regression analysis revealed that the strongest factor independently associated with steatosis was the carriage of the PNPLA3 rs738409 GG genotype (odds ratio [OR]/95% confidence intervals [CI]:2.34/1.557–3.515, P < 0.001). Among the patients with BMI < 24 kg/m(2), carriage of the rs738409 GG genotype was the only factor associated with hepatic steatosis (OR/CI:3.44/1.824–6.500, P < 0.001). PNPLA3 genetic variants had minimal effects on hepatic steatosis among overweight or obese patients. Compared to patients with BMI<24 kg/m(2)/non-GG genotype, those with BMI>24 kg/m(2)/GG genotype were more likely to have hepatic steatosis (OR/CI:3.87/2.292–6.524, P < 0.001). In conclusions, both PNPLA3 genetic variants and BMI played important roles in hepatic steatosis among Asian chronic hepatitis C patients. However, the genetic effect was mainly restricted to non-obese patients. Nature Publishing Group 2015-07-03 /pmc/articles/PMC4490397/ /pubmed/26139292 http://dx.doi.org/10.1038/srep11901 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Huang, Chung-Feng
Chen, Jyh-Jou
Yeh, Ming-Lun
Huang, Ching-I
Hsieh, Ming-Yen
Yang, Hua-Ling
Dai, Chia-Yen
Huang, Jee-Fu
Lin, Zu-Yau
Chen, Shinn-Cherng
Chuang, Wan-Long
Chen, Yao-Li
Yu, Ming-Lung
PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients
title PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients
title_full PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients
title_fullStr PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients
title_full_unstemmed PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients
title_short PNPLA3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis C patients
title_sort pnpla3 genetic variants determine hepatic steatosis in non-obese chronic hepatitis c patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490397/
https://www.ncbi.nlm.nih.gov/pubmed/26139292
http://dx.doi.org/10.1038/srep11901
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