Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

Inflammasome activation has been implicated in various inflammatory diseases including post-ischaemic inflammation after stroke. Inflammasomes mediate activation of caspase-1, which subsequently induces secretion of pro-inflammatory cytokines such as IL-1β and IL-18, as well as a form of cell death...

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Detalles Bibliográficos
Autores principales: Ito, Minako, Shichita, Takashi, Okada, Masahiro, Komine, Ritsuko, Noguchi, Yoshiko, Yoshimura, Akihiko, Morita, Rimpei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490404/
https://www.ncbi.nlm.nih.gov/pubmed/26059659
http://dx.doi.org/10.1038/ncomms8360

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