Insights into the origin of the nuclear localization signals in conserved ribosomal proteins

Eukaryotic ribosomal proteins, unlike their bacterial homologues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly. Here we provide a comprehensive comparison of bacterial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins...

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Autores principales: Melnikov, Sergey, Ben-Shem, Adam, Yusupova, Gulnara, Yusupov, Marat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490412/
https://www.ncbi.nlm.nih.gov/pubmed/26066547
http://dx.doi.org/10.1038/ncomms8382
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author Melnikov, Sergey
Ben-Shem, Adam
Yusupova, Gulnara
Yusupov, Marat
author_facet Melnikov, Sergey
Ben-Shem, Adam
Yusupova, Gulnara
Yusupov, Marat
author_sort Melnikov, Sergey
collection PubMed
description Eukaryotic ribosomal proteins, unlike their bacterial homologues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly. Here we provide a comprehensive comparison of bacterial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins via remodelling of their RNA-binding domains. This finding enabled us to identify previously unknown NLSs in ribosomal proteins from humans, and suggests that, apart from promoting protein transport, NLSs may facilitate folding of ribosomal RNA.
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spelling pubmed-44904122015-07-13 Insights into the origin of the nuclear localization signals in conserved ribosomal proteins Melnikov, Sergey Ben-Shem, Adam Yusupova, Gulnara Yusupov, Marat Nat Commun Article Eukaryotic ribosomal proteins, unlike their bacterial homologues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly. Here we provide a comprehensive comparison of bacterial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins via remodelling of their RNA-binding domains. This finding enabled us to identify previously unknown NLSs in ribosomal proteins from humans, and suggests that, apart from promoting protein transport, NLSs may facilitate folding of ribosomal RNA. Nature Pub. Group 2015-06-11 /pmc/articles/PMC4490412/ /pubmed/26066547 http://dx.doi.org/10.1038/ncomms8382 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Melnikov, Sergey
Ben-Shem, Adam
Yusupova, Gulnara
Yusupov, Marat
Insights into the origin of the nuclear localization signals in conserved ribosomal proteins
title Insights into the origin of the nuclear localization signals in conserved ribosomal proteins
title_full Insights into the origin of the nuclear localization signals in conserved ribosomal proteins
title_fullStr Insights into the origin of the nuclear localization signals in conserved ribosomal proteins
title_full_unstemmed Insights into the origin of the nuclear localization signals in conserved ribosomal proteins
title_short Insights into the origin of the nuclear localization signals in conserved ribosomal proteins
title_sort insights into the origin of the nuclear localization signals in conserved ribosomal proteins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490412/
https://www.ncbi.nlm.nih.gov/pubmed/26066547
http://dx.doi.org/10.1038/ncomms8382
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AT yusupovagulnara insightsintotheoriginofthenuclearlocalizationsignalsinconservedribosomalproteins
AT yusupovmarat insightsintotheoriginofthenuclearlocalizationsignalsinconservedribosomalproteins

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