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Periostin Expression and Its Prognostic Value for Colorectal Cancer

Integrin is important for cell growth, invasion and metastasis, which are frequently observed in malignant tumors. The periostin (POSTN) gene encodes the ligand for integrin, one of the key focal adhesion proteins contributing to the formation of a structural link between the extracellular matrix an...

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Autores principales: Li, Zewu, Zhang, Xin, Yang, Yongmei, Yang, Sanhui, Dong, Zhaogang, Du, Lutao, Wang, Lili, Wang, Chuanxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490432/
https://www.ncbi.nlm.nih.gov/pubmed/26023718
http://dx.doi.org/10.3390/ijms160612108
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author Li, Zewu
Zhang, Xin
Yang, Yongmei
Yang, Sanhui
Dong, Zhaogang
Du, Lutao
Wang, Lili
Wang, Chuanxin
author_facet Li, Zewu
Zhang, Xin
Yang, Yongmei
Yang, Sanhui
Dong, Zhaogang
Du, Lutao
Wang, Lili
Wang, Chuanxin
author_sort Li, Zewu
collection PubMed
description Integrin is important for cell growth, invasion and metastasis, which are frequently observed in malignant tumors. The periostin (POSTN) gene encodes the ligand for integrin, one of the key focal adhesion proteins contributing to the formation of a structural link between the extracellular matrix and integrins. High expression levels of the POSTN gene are correlated with numerous human malignancies. We examined POSTN protein in colorectal cancer specimens from 115 patients by strictly following up using immunohistochemistry. Cytoplasm immunohistochemical staining showed POSTN protein expression in colorectal cancers. The positive expression rate of POSTN protein (59.13%, 68/115) in colorectal cancers was significantly higher than that in adjacent normal colon mucosa (0.47%, 11/109). POSTN over-expression in colorectal cancers was positively correlated with tumor size, differentiation, lymph node metastasis, serosal invasion, clinical stage and five-year survival rates. Further analysis showed that patients with advanced stage colorectal cancer and high POSTN expression levels had lower survival rates than those with early stage colorectal cancer and low POSTN expression levels. Overall, our results showed that POSTN played an important role in the progression of colorectal cancers.
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spelling pubmed-44904322015-07-07 Periostin Expression and Its Prognostic Value for Colorectal Cancer Li, Zewu Zhang, Xin Yang, Yongmei Yang, Sanhui Dong, Zhaogang Du, Lutao Wang, Lili Wang, Chuanxin Int J Mol Sci Article Integrin is important for cell growth, invasion and metastasis, which are frequently observed in malignant tumors. The periostin (POSTN) gene encodes the ligand for integrin, one of the key focal adhesion proteins contributing to the formation of a structural link between the extracellular matrix and integrins. High expression levels of the POSTN gene are correlated with numerous human malignancies. We examined POSTN protein in colorectal cancer specimens from 115 patients by strictly following up using immunohistochemistry. Cytoplasm immunohistochemical staining showed POSTN protein expression in colorectal cancers. The positive expression rate of POSTN protein (59.13%, 68/115) in colorectal cancers was significantly higher than that in adjacent normal colon mucosa (0.47%, 11/109). POSTN over-expression in colorectal cancers was positively correlated with tumor size, differentiation, lymph node metastasis, serosal invasion, clinical stage and five-year survival rates. Further analysis showed that patients with advanced stage colorectal cancer and high POSTN expression levels had lower survival rates than those with early stage colorectal cancer and low POSTN expression levels. Overall, our results showed that POSTN played an important role in the progression of colorectal cancers. MDPI 2015-05-27 /pmc/articles/PMC4490432/ /pubmed/26023718 http://dx.doi.org/10.3390/ijms160612108 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Zewu
Zhang, Xin
Yang, Yongmei
Yang, Sanhui
Dong, Zhaogang
Du, Lutao
Wang, Lili
Wang, Chuanxin
Periostin Expression and Its Prognostic Value for Colorectal Cancer
title Periostin Expression and Its Prognostic Value for Colorectal Cancer
title_full Periostin Expression and Its Prognostic Value for Colorectal Cancer
title_fullStr Periostin Expression and Its Prognostic Value for Colorectal Cancer
title_full_unstemmed Periostin Expression and Its Prognostic Value for Colorectal Cancer
title_short Periostin Expression and Its Prognostic Value for Colorectal Cancer
title_sort periostin expression and its prognostic value for colorectal cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490432/
https://www.ncbi.nlm.nih.gov/pubmed/26023718
http://dx.doi.org/10.3390/ijms160612108
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