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A Combined Pharmacophore Modeling, 3D QSAR and Virtual Screening Studies on Imidazopyridines as B-Raf Inhibitors

B-Raf kinase is an important target in treatment of cancers. In order to design and find potent B-Raf inhibitors (BRIs), 3D pharmacophore models were created using the Genetic Algorithm with Linear Assignment of Hypermolecular Alignment of Database (GALAHAD). The best pharmacophore model obtained wh...

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Detalles Bibliográficos
Autores principales:	Xie, Huiding, Chen, Lijun, Zhang, Jianqiang, Xie, Xiaoguang, Qiu, Kaixiong, Fu, Jijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490445/ https://www.ncbi.nlm.nih.gov/pubmed/26035757 http://dx.doi.org/10.3390/ijms160612307

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