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Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases

This paper discusses how the activity and expression of cyclooxygenases are influenced by vanadium compounds at anticancer concentrations and recorded in inorganic vanadium poisonings. We refer mainly to the effects of vanadate (orthovanadate), vanadyl and pervanadate ions; the main focus is placed...

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Autores principales: Korbecki, Jan, Baranowska-Bosiacka, Irena, Gutowska, Izabela, Chlubek, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490466/
https://www.ncbi.nlm.nih.gov/pubmed/26053397
http://dx.doi.org/10.3390/ijms160612648
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author Korbecki, Jan
Baranowska-Bosiacka, Irena
Gutowska, Izabela
Chlubek, Dariusz
author_facet Korbecki, Jan
Baranowska-Bosiacka, Irena
Gutowska, Izabela
Chlubek, Dariusz
author_sort Korbecki, Jan
collection PubMed
description This paper discusses how the activity and expression of cyclooxygenases are influenced by vanadium compounds at anticancer concentrations and recorded in inorganic vanadium poisonings. We refer mainly to the effects of vanadate (orthovanadate), vanadyl and pervanadate ions; the main focus is placed on their impact on intracellular signaling. We describe the exact mechanism of the effect of vanadium compounds on protein tyrosine phosphatases (PTP), epidermal growth factor receptor (EGFR), PLCγ, Src, mitogen-activated protein kinase (MAPK) cascades, transcription factor NF-κB, the effect on the proteolysis of COX-2 and the activity of cPLA(2). For a better understanding of these processes, a lot of space is devoted to the transformation of vanadium compounds within the cell and the molecular influence on the direct targets of the discussed vanadium compounds.
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spelling pubmed-44904662015-07-07 Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases Korbecki, Jan Baranowska-Bosiacka, Irena Gutowska, Izabela Chlubek, Dariusz Int J Mol Sci Review This paper discusses how the activity and expression of cyclooxygenases are influenced by vanadium compounds at anticancer concentrations and recorded in inorganic vanadium poisonings. We refer mainly to the effects of vanadate (orthovanadate), vanadyl and pervanadate ions; the main focus is placed on their impact on intracellular signaling. We describe the exact mechanism of the effect of vanadium compounds on protein tyrosine phosphatases (PTP), epidermal growth factor receptor (EGFR), PLCγ, Src, mitogen-activated protein kinase (MAPK) cascades, transcription factor NF-κB, the effect on the proteolysis of COX-2 and the activity of cPLA(2). For a better understanding of these processes, a lot of space is devoted to the transformation of vanadium compounds within the cell and the molecular influence on the direct targets of the discussed vanadium compounds. MDPI 2015-06-04 /pmc/articles/PMC4490466/ /pubmed/26053397 http://dx.doi.org/10.3390/ijms160612648 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Korbecki, Jan
Baranowska-Bosiacka, Irena
Gutowska, Izabela
Chlubek, Dariusz
Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases
title Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases
title_full Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases
title_fullStr Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases
title_full_unstemmed Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases
title_short Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases
title_sort vanadium compounds as pro-inflammatory agents: effects on cyclooxygenases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490466/
https://www.ncbi.nlm.nih.gov/pubmed/26053397
http://dx.doi.org/10.3390/ijms160612648
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AT chlubekdariusz vanadiumcompoundsasproinflammatoryagentseffectsoncyclooxygenases