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Families of microRNAs Expressed in Clusters Regulate Cell Signaling in Cervical Cancer
Tumor cells have developed advantages to acquire hallmarks of cancer like apoptosis resistance, increased proliferation, migration, and invasion through cell signaling pathway misregulation. The sequential activation of genes in a pathway is regulated by miRNAs. Loss or gain of miRNA expression coul...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490472/ https://www.ncbi.nlm.nih.gov/pubmed/26057746 http://dx.doi.org/10.3390/ijms160612773 |
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author | Servín-González, Luis Steven Granados-López, Angelica Judith López, Jesús Adrián |
author_facet | Servín-González, Luis Steven Granados-López, Angelica Judith López, Jesús Adrián |
author_sort | Servín-González, Luis Steven |
collection | PubMed |
description | Tumor cells have developed advantages to acquire hallmarks of cancer like apoptosis resistance, increased proliferation, migration, and invasion through cell signaling pathway misregulation. The sequential activation of genes in a pathway is regulated by miRNAs. Loss or gain of miRNA expression could activate or repress a particular cell axis. It is well known that aberrant miRNA expression is well recognized as an important step in the development of cancer. Individual miRNA expression is reported without considering that miRNAs are grouped in clusters and may have similar functions, such as the case of clusters with anti-oncomiRs (23b~27b~24-1, miR-29a~29b-1, miR-29b-2~29c, miR-99a~125b-2, miR-99b~125a, miR-100~125b-1, miR-199a-2~214, and miR-302s) or oncomiRs activity (miR-1-1~133a-2, miR-1-2~133a-1, miR-133b~206, miR-17~92, miR-106a~363, miR183~96~182, miR-181a-1~181b-1, and miR-181a-2~181b-2), which regulated mitogen-activated protein kinases (MAPK), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), NOTCH, proteasome-culling rings, and apoptosis cell signaling. In this work we point out the pathways regulated by families of miRNAs grouped in 20 clusters involved in cervical cancer. Reviewing how miRNA families expressed in cluster-regulated cell path signaling will increase the knowledge of cervical cancer progression, providing important information for therapeutic, diagnostic, and prognostic methodology design. |
format | Online Article Text |
id | pubmed-4490472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44904722015-07-07 Families of microRNAs Expressed in Clusters Regulate Cell Signaling in Cervical Cancer Servín-González, Luis Steven Granados-López, Angelica Judith López, Jesús Adrián Int J Mol Sci Review Tumor cells have developed advantages to acquire hallmarks of cancer like apoptosis resistance, increased proliferation, migration, and invasion through cell signaling pathway misregulation. The sequential activation of genes in a pathway is regulated by miRNAs. Loss or gain of miRNA expression could activate or repress a particular cell axis. It is well known that aberrant miRNA expression is well recognized as an important step in the development of cancer. Individual miRNA expression is reported without considering that miRNAs are grouped in clusters and may have similar functions, such as the case of clusters with anti-oncomiRs (23b~27b~24-1, miR-29a~29b-1, miR-29b-2~29c, miR-99a~125b-2, miR-99b~125a, miR-100~125b-1, miR-199a-2~214, and miR-302s) or oncomiRs activity (miR-1-1~133a-2, miR-1-2~133a-1, miR-133b~206, miR-17~92, miR-106a~363, miR183~96~182, miR-181a-1~181b-1, and miR-181a-2~181b-2), which regulated mitogen-activated protein kinases (MAPK), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K), NOTCH, proteasome-culling rings, and apoptosis cell signaling. In this work we point out the pathways regulated by families of miRNAs grouped in 20 clusters involved in cervical cancer. Reviewing how miRNA families expressed in cluster-regulated cell path signaling will increase the knowledge of cervical cancer progression, providing important information for therapeutic, diagnostic, and prognostic methodology design. MDPI 2015-06-05 /pmc/articles/PMC4490472/ /pubmed/26057746 http://dx.doi.org/10.3390/ijms160612773 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Servín-González, Luis Steven Granados-López, Angelica Judith López, Jesús Adrián Families of microRNAs Expressed in Clusters Regulate Cell Signaling in Cervical Cancer |
title | Families of microRNAs Expressed in Clusters Regulate Cell Signaling in Cervical Cancer |
title_full | Families of microRNAs Expressed in Clusters Regulate Cell Signaling in Cervical Cancer |
title_fullStr | Families of microRNAs Expressed in Clusters Regulate Cell Signaling in Cervical Cancer |
title_full_unstemmed | Families of microRNAs Expressed in Clusters Regulate Cell Signaling in Cervical Cancer |
title_short | Families of microRNAs Expressed in Clusters Regulate Cell Signaling in Cervical Cancer |
title_sort | families of micrornas expressed in clusters regulate cell signaling in cervical cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490472/ https://www.ncbi.nlm.nih.gov/pubmed/26057746 http://dx.doi.org/10.3390/ijms160612773 |
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