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The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking
Single nucleotide polymorphisms (SNPs) of the USF1 gene (upstream stimulatory factor 1) influence plasma lipid levels. This study aims to determine whether USF1 SNPs interact with traditional risk factors of atherosclerosis to increase coronary artery disease (CAD) risk. In the present study serum l...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490492/ https://www.ncbi.nlm.nih.gov/pubmed/26068452 http://dx.doi.org/10.3390/ijms160613203 |
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author | Niemiec, Pawel Nowak, Tomasz Iwanicki, Tomasz Gorczynska-Kosiorz, Sylwia Balcerzyk, Anna Krauze, Jolanta Grzeszczak, Wladyslaw Wiecha, Maria Zak, Iwona |
author_facet | Niemiec, Pawel Nowak, Tomasz Iwanicki, Tomasz Gorczynska-Kosiorz, Sylwia Balcerzyk, Anna Krauze, Jolanta Grzeszczak, Wladyslaw Wiecha, Maria Zak, Iwona |
author_sort | Niemiec, Pawel |
collection | PubMed |
description | Single nucleotide polymorphisms (SNPs) of the USF1 gene (upstream stimulatory factor 1) influence plasma lipid levels. This study aims to determine whether USF1 SNPs interact with traditional risk factors of atherosclerosis to increase coronary artery disease (CAD) risk. In the present study serum lipid levels and USF1 gene polymorphisms (rs2516839 and rs3737787) were determined in 470 subjects: 235 patients with premature CAD and 235 controls. A trend of increasing triglycerides (TG) levels in relation to the C allele dose of rs2516839 SNP was observed. The synergistic effect of cigarette smoking and C allele carrier state on CAD risk was also found (SIM = 2.69, p = 0.015). TG levels differentiated significantly particular genotypes in smokers (1.53 mmol/L for TT, 1.80 mmol/L for CT and 2.27 mmol/L for CC subjects). In contrast, these differences were not observed in the non-smokers subgroup (1.57 mmol/L for TT, 1.46 mmol/L for CT and 1.49 mmol/L for CC subjects). In conclusion, the rs2516839 polymorphism may modulate serum triglyceride levels in response to cigarette smoking. Carriers of the C allele seem to be particularly at risk of CAD, when exposed to cigarette smoking. |
format | Online Article Text |
id | pubmed-4490492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44904922015-07-07 The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking Niemiec, Pawel Nowak, Tomasz Iwanicki, Tomasz Gorczynska-Kosiorz, Sylwia Balcerzyk, Anna Krauze, Jolanta Grzeszczak, Wladyslaw Wiecha, Maria Zak, Iwona Int J Mol Sci Article Single nucleotide polymorphisms (SNPs) of the USF1 gene (upstream stimulatory factor 1) influence plasma lipid levels. This study aims to determine whether USF1 SNPs interact with traditional risk factors of atherosclerosis to increase coronary artery disease (CAD) risk. In the present study serum lipid levels and USF1 gene polymorphisms (rs2516839 and rs3737787) were determined in 470 subjects: 235 patients with premature CAD and 235 controls. A trend of increasing triglycerides (TG) levels in relation to the C allele dose of rs2516839 SNP was observed. The synergistic effect of cigarette smoking and C allele carrier state on CAD risk was also found (SIM = 2.69, p = 0.015). TG levels differentiated significantly particular genotypes in smokers (1.53 mmol/L for TT, 1.80 mmol/L for CT and 2.27 mmol/L for CC subjects). In contrast, these differences were not observed in the non-smokers subgroup (1.57 mmol/L for TT, 1.46 mmol/L for CT and 1.49 mmol/L for CC subjects). In conclusion, the rs2516839 polymorphism may modulate serum triglyceride levels in response to cigarette smoking. Carriers of the C allele seem to be particularly at risk of CAD, when exposed to cigarette smoking. MDPI 2015-06-10 /pmc/articles/PMC4490492/ /pubmed/26068452 http://dx.doi.org/10.3390/ijms160613203 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Niemiec, Pawel Nowak, Tomasz Iwanicki, Tomasz Gorczynska-Kosiorz, Sylwia Balcerzyk, Anna Krauze, Jolanta Grzeszczak, Wladyslaw Wiecha, Maria Zak, Iwona The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking |
title | The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking |
title_full | The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking |
title_fullStr | The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking |
title_full_unstemmed | The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking |
title_short | The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking |
title_sort | rs2516839 polymorphism of the usf1 gene may modulate serum triglyceride levels in response to cigarette smoking |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490492/ https://www.ncbi.nlm.nih.gov/pubmed/26068452 http://dx.doi.org/10.3390/ijms160613203 |
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