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The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking

Single nucleotide polymorphisms (SNPs) of the USF1 gene (upstream stimulatory factor 1) influence plasma lipid levels. This study aims to determine whether USF1 SNPs interact with traditional risk factors of atherosclerosis to increase coronary artery disease (CAD) risk. In the present study serum l...

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Autores principales: Niemiec, Pawel, Nowak, Tomasz, Iwanicki, Tomasz, Gorczynska-Kosiorz, Sylwia, Balcerzyk, Anna, Krauze, Jolanta, Grzeszczak, Wladyslaw, Wiecha, Maria, Zak, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490492/
https://www.ncbi.nlm.nih.gov/pubmed/26068452
http://dx.doi.org/10.3390/ijms160613203
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author Niemiec, Pawel
Nowak, Tomasz
Iwanicki, Tomasz
Gorczynska-Kosiorz, Sylwia
Balcerzyk, Anna
Krauze, Jolanta
Grzeszczak, Wladyslaw
Wiecha, Maria
Zak, Iwona
author_facet Niemiec, Pawel
Nowak, Tomasz
Iwanicki, Tomasz
Gorczynska-Kosiorz, Sylwia
Balcerzyk, Anna
Krauze, Jolanta
Grzeszczak, Wladyslaw
Wiecha, Maria
Zak, Iwona
author_sort Niemiec, Pawel
collection PubMed
description Single nucleotide polymorphisms (SNPs) of the USF1 gene (upstream stimulatory factor 1) influence plasma lipid levels. This study aims to determine whether USF1 SNPs interact with traditional risk factors of atherosclerosis to increase coronary artery disease (CAD) risk. In the present study serum lipid levels and USF1 gene polymorphisms (rs2516839 and rs3737787) were determined in 470 subjects: 235 patients with premature CAD and 235 controls. A trend of increasing triglycerides (TG) levels in relation to the C allele dose of rs2516839 SNP was observed. The synergistic effect of cigarette smoking and C allele carrier state on CAD risk was also found (SIM = 2.69, p = 0.015). TG levels differentiated significantly particular genotypes in smokers (1.53 mmol/L for TT, 1.80 mmol/L for CT and 2.27 mmol/L for CC subjects). In contrast, these differences were not observed in the non-smokers subgroup (1.57 mmol/L for TT, 1.46 mmol/L for CT and 1.49 mmol/L for CC subjects). In conclusion, the rs2516839 polymorphism may modulate serum triglyceride levels in response to cigarette smoking. Carriers of the C allele seem to be particularly at risk of CAD, when exposed to cigarette smoking.
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spelling pubmed-44904922015-07-07 The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking Niemiec, Pawel Nowak, Tomasz Iwanicki, Tomasz Gorczynska-Kosiorz, Sylwia Balcerzyk, Anna Krauze, Jolanta Grzeszczak, Wladyslaw Wiecha, Maria Zak, Iwona Int J Mol Sci Article Single nucleotide polymorphisms (SNPs) of the USF1 gene (upstream stimulatory factor 1) influence plasma lipid levels. This study aims to determine whether USF1 SNPs interact with traditional risk factors of atherosclerosis to increase coronary artery disease (CAD) risk. In the present study serum lipid levels and USF1 gene polymorphisms (rs2516839 and rs3737787) were determined in 470 subjects: 235 patients with premature CAD and 235 controls. A trend of increasing triglycerides (TG) levels in relation to the C allele dose of rs2516839 SNP was observed. The synergistic effect of cigarette smoking and C allele carrier state on CAD risk was also found (SIM = 2.69, p = 0.015). TG levels differentiated significantly particular genotypes in smokers (1.53 mmol/L for TT, 1.80 mmol/L for CT and 2.27 mmol/L for CC subjects). In contrast, these differences were not observed in the non-smokers subgroup (1.57 mmol/L for TT, 1.46 mmol/L for CT and 1.49 mmol/L for CC subjects). In conclusion, the rs2516839 polymorphism may modulate serum triglyceride levels in response to cigarette smoking. Carriers of the C allele seem to be particularly at risk of CAD, when exposed to cigarette smoking. MDPI 2015-06-10 /pmc/articles/PMC4490492/ /pubmed/26068452 http://dx.doi.org/10.3390/ijms160613203 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Niemiec, Pawel
Nowak, Tomasz
Iwanicki, Tomasz
Gorczynska-Kosiorz, Sylwia
Balcerzyk, Anna
Krauze, Jolanta
Grzeszczak, Wladyslaw
Wiecha, Maria
Zak, Iwona
The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking
title The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking
title_full The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking
title_fullStr The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking
title_full_unstemmed The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking
title_short The rs2516839 Polymorphism of the USF1 Gene May Modulate Serum Triglyceride Levels in Response to Cigarette Smoking
title_sort rs2516839 polymorphism of the usf1 gene may modulate serum triglyceride levels in response to cigarette smoking
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490492/
https://www.ncbi.nlm.nih.gov/pubmed/26068452
http://dx.doi.org/10.3390/ijms160613203
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