Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis

Cells are protected from toxic DNA double-stranded breaks (DSBs) by a number of DNA repair mechanisms, including some that are intrinsically error prone, thus resulting in mutations. To what extent these mechanisms contribute to evolutionary diversification remains unknown. Here, we demonstrate that...

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Detalles Bibliográficos
Autores principales: van Schendel, Robin, Roerink, Sophie F., Portegijs, Vincent, van den Heuvel, Sander, Tijsterman, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490562/
https://www.ncbi.nlm.nih.gov/pubmed/26077599
http://dx.doi.org/10.1038/ncomms8394

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