Systemic immunity shapes the oral microbiome and susceptibility to bisphosphonate-associated osteonecrosis of the jaw

BACKGROUND: Osteonecrosis of the jaw (ONJ) is a rare but serious adverse drug effect linked to long-term and/or high-dose exposure to nitrogen-bisphosphonates (N-BP), the standard of care for the treatment of bone fragility disorders. The mechanism leading to bisphosphonate-associated ONJ (BAONJ) is...

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Detalles Bibliográficos
Autores principales: Kalyan, Shirin, Wang, Jun, Quabius, Elgar Susanne, Huck, Jörn, Wiltfang, Jörg, Baines, John F, Kabelitz, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490596/
https://www.ncbi.nlm.nih.gov/pubmed/26141514
http://dx.doi.org/10.1186/s12967-015-0568-z

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