Hydromethylation of Unactivated Olefins

[Image: see text] A solution to the classic unsolved problem of olefin hydromethylation is presented. This highly chemoselective method can tolerate labile and reactive chemical functionalities and uses a simple set of reagents. An array of olefins, including mono-, di-, and trisubstituted olefins,...

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Autores principales: Dao, Hai T., Li, Chao, Michaudel, Quentin, Maxwell, Brad D., Baran, Phil S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490774/
https://www.ncbi.nlm.nih.gov/pubmed/26088401
http://dx.doi.org/10.1021/jacs.5b05144
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author Dao, Hai T.
Li, Chao
Michaudel, Quentin
Maxwell, Brad D.
Baran, Phil S.
author_facet Dao, Hai T.
Li, Chao
Michaudel, Quentin
Maxwell, Brad D.
Baran, Phil S.
author_sort Dao, Hai T.
collection PubMed
description [Image: see text] A solution to the classic unsolved problem of olefin hydromethylation is presented. This highly chemoselective method can tolerate labile and reactive chemical functionalities and uses a simple set of reagents. An array of olefins, including mono-, di-, and trisubstituted olefins, are all smoothly hydromethylated. This mild protocol can be used to simplify the synthesis of a specific target or to directly “edit” complex natural products and other advanced materials. The method is also amenable to the simple installation of radioactive and stable labeled methyl groups.
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spelling pubmed-44907742015-07-06 Hydromethylation of Unactivated Olefins Dao, Hai T. Li, Chao Michaudel, Quentin Maxwell, Brad D. Baran, Phil S. J Am Chem Soc [Image: see text] A solution to the classic unsolved problem of olefin hydromethylation is presented. This highly chemoselective method can tolerate labile and reactive chemical functionalities and uses a simple set of reagents. An array of olefins, including mono-, di-, and trisubstituted olefins, are all smoothly hydromethylated. This mild protocol can be used to simplify the synthesis of a specific target or to directly “edit” complex natural products and other advanced materials. The method is also amenable to the simple installation of radioactive and stable labeled methyl groups. American Chemical Society 2015-06-19 2015-07-01 /pmc/articles/PMC4490774/ /pubmed/26088401 http://dx.doi.org/10.1021/jacs.5b05144 Text en Copyright © 2015 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Dao, Hai T.
Li, Chao
Michaudel, Quentin
Maxwell, Brad D.
Baran, Phil S.
Hydromethylation of Unactivated Olefins
title Hydromethylation of Unactivated Olefins
title_full Hydromethylation of Unactivated Olefins
title_fullStr Hydromethylation of Unactivated Olefins
title_full_unstemmed Hydromethylation of Unactivated Olefins
title_short Hydromethylation of Unactivated Olefins
title_sort hydromethylation of unactivated olefins
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490774/
https://www.ncbi.nlm.nih.gov/pubmed/26088401
http://dx.doi.org/10.1021/jacs.5b05144
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