Draft Genome Sequences of Two Pyrazinamide-Resistant Clinical Isolates, Mycobacterium tuberculosis 13-4152 and 13-2459

We report draft genome sequences of two pyrazinamide (PZA)-resistant isolates, Mycobacterium tuberculosis 13-4152 and 13-2459. Isolate 13-4152 is PZA resistant, though it lacks mutations in known genes of PZA resistance. The comparative analysis of these genomes with those stored in GenBank revealed...

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Autores principales: Maslov, D. A., Shur, K. V., Bekker, O. B., Zakharevich, N. V., Zaichikova, M. V., Klimina, K. M., Smirnova, T. G., Zhang, Y., Chernousova, L. N., Danilenko, V. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2015
Materias:
Prokaryotes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490854/
https://www.ncbi.nlm.nih.gov/pubmed/26139726
http://dx.doi.org/10.1128/genomeA.00758-15
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author Maslov, D. A.
Shur, K. V.
Bekker, O. B.
Zakharevich, N. V.
Zaichikova, M. V.
Klimina, K. M.
Smirnova, T. G.
Zhang, Y.
Chernousova, L. N.
Danilenko, V. N.
author_facet Maslov, D. A.
Shur, K. V.
Bekker, O. B.
Zakharevich, N. V.
Zaichikova, M. V.
Klimina, K. M.
Smirnova, T. G.
Zhang, Y.
Chernousova, L. N.
Danilenko, V. N.
author_sort Maslov, D. A.
collection PubMed
description We report draft genome sequences of two pyrazinamide (PZA)-resistant isolates, Mycobacterium tuberculosis 13-4152 and 13-2459. Isolate 13-4152 is PZA resistant, though it lacks mutations in known genes of PZA resistance. The comparative analysis of these genomes with those stored in GenBank revealed unique mutations, which may elucidate new mechanisms of PZA resistance.
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spelling pubmed-44908542015-07-10 Draft Genome Sequences of Two Pyrazinamide-Resistant Clinical Isolates, Mycobacterium tuberculosis 13-4152 and 13-2459 Maslov, D. A. Shur, K. V. Bekker, O. B. Zakharevich, N. V. Zaichikova, M. V. Klimina, K. M. Smirnova, T. G. Zhang, Y. Chernousova, L. N. Danilenko, V. N. Genome Announc Prokaryotes We report draft genome sequences of two pyrazinamide (PZA)-resistant isolates, Mycobacterium tuberculosis 13-4152 and 13-2459. Isolate 13-4152 is PZA resistant, though it lacks mutations in known genes of PZA resistance. The comparative analysis of these genomes with those stored in GenBank revealed unique mutations, which may elucidate new mechanisms of PZA resistance. American Society for Microbiology 2015-07-02 /pmc/articles/PMC4490854/ /pubmed/26139726 http://dx.doi.org/10.1128/genomeA.00758-15 Text en Copyright © 2015 Maslov et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Prokaryotes
Maslov, D. A.
Shur, K. V.
Bekker, O. B.
Zakharevich, N. V.
Zaichikova, M. V.
Klimina, K. M.
Smirnova, T. G.
Zhang, Y.
Chernousova, L. N.
Danilenko, V. N.
Draft Genome Sequences of Two Pyrazinamide-Resistant Clinical Isolates, Mycobacterium tuberculosis 13-4152 and 13-2459
title Draft Genome Sequences of Two Pyrazinamide-Resistant Clinical Isolates, Mycobacterium tuberculosis 13-4152 and 13-2459
title_full Draft Genome Sequences of Two Pyrazinamide-Resistant Clinical Isolates, Mycobacterium tuberculosis 13-4152 and 13-2459
title_fullStr Draft Genome Sequences of Two Pyrazinamide-Resistant Clinical Isolates, Mycobacterium tuberculosis 13-4152 and 13-2459
title_full_unstemmed Draft Genome Sequences of Two Pyrazinamide-Resistant Clinical Isolates, Mycobacterium tuberculosis 13-4152 and 13-2459
title_short Draft Genome Sequences of Two Pyrazinamide-Resistant Clinical Isolates, Mycobacterium tuberculosis 13-4152 and 13-2459
title_sort draft genome sequences of two pyrazinamide-resistant clinical isolates, mycobacterium tuberculosis 13-4152 and 13-2459
topic Prokaryotes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490854/
https://www.ncbi.nlm.nih.gov/pubmed/26139726
http://dx.doi.org/10.1128/genomeA.00758-15
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