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Hypoxia induces calpain activity and degrades SMAD2 to attenuate TGFβ signaling in macrophages
BACKGROUND: Under inflammatory conditions or during tumor progression macrophages acquire distinct phenotypes, with factors of the microenvironment such as hypoxia and transforming growth factor β (TGFβ) shaping their functional plasticity. TGFβ is among the factors causing alternative macrophage ac...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491253/ https://www.ncbi.nlm.nih.gov/pubmed/26146544 http://dx.doi.org/10.1186/s13578-015-0026-x |