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DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter

INTRODUCTION: Sclerostin (SOST), a soluble antagonist of Wnt signaling, is expressed in chondrocytes and contributes to chondrocytes’ hypertrophic differentiation; however its role in osteoarthritis (OA) pathogenesis is not well known. Based on our previous findings on the interaction between Wnt/β-...

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Detalles Bibliográficos
Autores principales:	Papathanasiou, Ioanna, Kostopoulou, Fotini, Malizos, Konstantinos N., Tsezou, Aspasia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491261/ https://www.ncbi.nlm.nih.gov/pubmed/26071314 http://dx.doi.org/10.1186/s13075-015-0674-6

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