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Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion
Objective. To test the feasibility of a CT-compatible, ex vivo, perfused porcine heart model for myocardial perfusion CT imaging. Methods. One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory pa...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491382/ https://www.ncbi.nlm.nih.gov/pubmed/26185756 http://dx.doi.org/10.1155/2015/412716 |
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author | Pelgrim, Gert Jan Das, Marco Haberland, Ulrike Slump, Cees Handayani, Astri van Tuijl, Sjoerd Stijnen, Marco Klotz, Ernst Oudkerk, Matthijs Wildberger, Joachim E. Vliegenthart, Rozemarijn |
author_facet | Pelgrim, Gert Jan Das, Marco Haberland, Ulrike Slump, Cees Handayani, Astri van Tuijl, Sjoerd Stijnen, Marco Klotz, Ernst Oudkerk, Matthijs Wildberger, Joachim E. Vliegenthart, Rozemarijn |
author_sort | Pelgrim, Gert Jan |
collection | PubMed |
description | Objective. To test the feasibility of a CT-compatible, ex vivo, perfused porcine heart model for myocardial perfusion CT imaging. Methods. One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve (FFR) pressure wire. CT-derived myocardial perfusion parameters were analysed at FFR of 1 to 0.10/0.0. Results. CT images did not show major artefacts due to interference of the model setup. The pacemaker-induced heart rhythm was generally stable at 70 beats per minute. During most of the experiment, blood flow was 0.9–1.0 L/min, and arterial pressure varied between 80 and 95 mm/Hg. Blood flow decreased and arterial pressure increased by approximately 10% after inducing a stenosis with FFR ≤ 0.50. Dynamic perfusion scanning was possible across the range of stenosis grades. Perfusion parameters of circumflex-perfused myocardial segments were affected at increasing stenosis grades. Conclusion. An adapted Langendorff porcine heart model is feasible in a CT environment. This model provides control over physiological parameters and may allow in-depth validation of quantitative CT perfusion techniques. |
format | Online Article Text |
id | pubmed-4491382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44913822015-07-16 Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion Pelgrim, Gert Jan Das, Marco Haberland, Ulrike Slump, Cees Handayani, Astri van Tuijl, Sjoerd Stijnen, Marco Klotz, Ernst Oudkerk, Matthijs Wildberger, Joachim E. Vliegenthart, Rozemarijn Biomed Res Int Research Article Objective. To test the feasibility of a CT-compatible, ex vivo, perfused porcine heart model for myocardial perfusion CT imaging. Methods. One porcine heart was perfused according to Langendorff. Dynamic perfusion scanning was performed with a second-generation dual source CT scanner. Circulatory parameters like blood flow, aortic pressure, and heart rate were monitored throughout the experiment. Stenosis was induced in the circumflex artery, controlled by a fractional flow reserve (FFR) pressure wire. CT-derived myocardial perfusion parameters were analysed at FFR of 1 to 0.10/0.0. Results. CT images did not show major artefacts due to interference of the model setup. The pacemaker-induced heart rhythm was generally stable at 70 beats per minute. During most of the experiment, blood flow was 0.9–1.0 L/min, and arterial pressure varied between 80 and 95 mm/Hg. Blood flow decreased and arterial pressure increased by approximately 10% after inducing a stenosis with FFR ≤ 0.50. Dynamic perfusion scanning was possible across the range of stenosis grades. Perfusion parameters of circumflex-perfused myocardial segments were affected at increasing stenosis grades. Conclusion. An adapted Langendorff porcine heart model is feasible in a CT environment. This model provides control over physiological parameters and may allow in-depth validation of quantitative CT perfusion techniques. Hindawi Publishing Corporation 2015 2015-06-21 /pmc/articles/PMC4491382/ /pubmed/26185756 http://dx.doi.org/10.1155/2015/412716 Text en Copyright © 2015 Gert Jan Pelgrim et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Pelgrim, Gert Jan Das, Marco Haberland, Ulrike Slump, Cees Handayani, Astri van Tuijl, Sjoerd Stijnen, Marco Klotz, Ernst Oudkerk, Matthijs Wildberger, Joachim E. Vliegenthart, Rozemarijn Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion |
title | Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion |
title_full | Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion |
title_fullStr | Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion |
title_full_unstemmed | Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion |
title_short | Development of an Ex Vivo, Beating Heart Model for CT Myocardial Perfusion |
title_sort | development of an ex vivo, beating heart model for ct myocardial perfusion |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491382/ https://www.ncbi.nlm.nih.gov/pubmed/26185756 http://dx.doi.org/10.1155/2015/412716 |
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