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Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study

Immunodeficiency is associated with higher cancer incidence. However, it is unknown whether there is a link between immunodeficiency and development of multiple primary malignancies. In the present study we analyse this link focusing on kidney-transplanted patients, as they are at higher risk of dev...

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Autores principales: Santangelo, Michele L., Criscitiello, Carmen, Renda, Andrea, Federico, Stefano, Curigliano, Giuseppe, Dodaro, Concetta, Scotti, Alessandro, Tammaro, Vincenzo, Calogero, Armando, Riccio, Eleonora, Pisani, Antonio, Carlomagno, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491567/
https://www.ncbi.nlm.nih.gov/pubmed/26185750
http://dx.doi.org/10.1155/2015/183523
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author Santangelo, Michele L.
Criscitiello, Carmen
Renda, Andrea
Federico, Stefano
Curigliano, Giuseppe
Dodaro, Concetta
Scotti, Alessandro
Tammaro, Vincenzo
Calogero, Armando
Riccio, Eleonora
Pisani, Antonio
Carlomagno, Nicola
author_facet Santangelo, Michele L.
Criscitiello, Carmen
Renda, Andrea
Federico, Stefano
Curigliano, Giuseppe
Dodaro, Concetta
Scotti, Alessandro
Tammaro, Vincenzo
Calogero, Armando
Riccio, Eleonora
Pisani, Antonio
Carlomagno, Nicola
author_sort Santangelo, Michele L.
collection PubMed
description Immunodeficiency is associated with higher cancer incidence. However, it is unknown whether there is a link between immunodeficiency and development of multiple primary malignancies. In the present study we analyse this link focusing on kidney-transplanted patients, as they are at higher risk of developing cancer due to the chronic assumption of immunosuppressants. We followed up 1200 patients who underwent kidney transplantation between 1980 and 2012. A total of 77/1200 kidney-transplanted patients developed cancer and 24 of them developed multiple cancers. Most multiple cancers were synchronous with a nonsignificant association between cancer and rejection episodes. In the general cancer population, one-ninth of patients are at higher risk of developing a second tumor over a lifetime; hence it would be reasonable to conclude that, from a merely theoretical and statistical viewpoint, long-term transplanted patients potentially have a higher risk of developing MPMs. However, data did not confirm this assumption, probably because these patients die before a second primary malignancy appears. Despite many observations on the increased incidence of different tumor types in immunodeficient patients and despite immunosuppression certainly being a predisposing factor for the multicancer syndrome, data so far are not robust enough to justify a correlation between immunodeficiency and multiple primary malignancies in transplanted patients.
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spelling pubmed-44915672015-07-16 Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study Santangelo, Michele L. Criscitiello, Carmen Renda, Andrea Federico, Stefano Curigliano, Giuseppe Dodaro, Concetta Scotti, Alessandro Tammaro, Vincenzo Calogero, Armando Riccio, Eleonora Pisani, Antonio Carlomagno, Nicola Biomed Res Int Research Article Immunodeficiency is associated with higher cancer incidence. However, it is unknown whether there is a link between immunodeficiency and development of multiple primary malignancies. In the present study we analyse this link focusing on kidney-transplanted patients, as they are at higher risk of developing cancer due to the chronic assumption of immunosuppressants. We followed up 1200 patients who underwent kidney transplantation between 1980 and 2012. A total of 77/1200 kidney-transplanted patients developed cancer and 24 of them developed multiple cancers. Most multiple cancers were synchronous with a nonsignificant association between cancer and rejection episodes. In the general cancer population, one-ninth of patients are at higher risk of developing a second tumor over a lifetime; hence it would be reasonable to conclude that, from a merely theoretical and statistical viewpoint, long-term transplanted patients potentially have a higher risk of developing MPMs. However, data did not confirm this assumption, probably because these patients die before a second primary malignancy appears. Despite many observations on the increased incidence of different tumor types in immunodeficient patients and despite immunosuppression certainly being a predisposing factor for the multicancer syndrome, data so far are not robust enough to justify a correlation between immunodeficiency and multiple primary malignancies in transplanted patients. Hindawi Publishing Corporation 2015 2015-06-22 /pmc/articles/PMC4491567/ /pubmed/26185750 http://dx.doi.org/10.1155/2015/183523 Text en Copyright © 2015 Michele L. Santangelo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Santangelo, Michele L.
Criscitiello, Carmen
Renda, Andrea
Federico, Stefano
Curigliano, Giuseppe
Dodaro, Concetta
Scotti, Alessandro
Tammaro, Vincenzo
Calogero, Armando
Riccio, Eleonora
Pisani, Antonio
Carlomagno, Nicola
Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study
title Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study
title_full Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study
title_fullStr Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study
title_full_unstemmed Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study
title_short Immunosuppression and Multiple Primary Malignancies in Kidney-Transplanted Patients: A Single-Institute Study
title_sort immunosuppression and multiple primary malignancies in kidney-transplanted patients: a single-institute study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491567/
https://www.ncbi.nlm.nih.gov/pubmed/26185750
http://dx.doi.org/10.1155/2015/183523
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