Inhibiting phosphorylation of the oncogenic PAX3-FOXO1 reduces alveolar rhabdomyosarcoma phenotypes identifying novel therapy options

Patients with translocation-positive alveolar rhabdomyosarcoma (ARMS), an aggressive childhood tumor primarily characterized by the PAX3-FOXO1 oncogenic fusion protein, have a poor prognosis because of lack of therapies that specifically target ARMS tumors. This fact highlights the need for novel ph...

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Detalles Bibliográficos
Autores principales: Loupe, J M, Miller, P J, Ruffin, D R, Stark, M W, Hollenbach, A D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491609/
https://www.ncbi.nlm.nih.gov/pubmed/25821947
http://dx.doi.org/10.1038/oncsis.2015.2

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