Cargando…
Conduction block in myelinated axons induced by high-frequency (kHz) non-symmetric biphasic stimulation
This study used the Frankenhaeuser–Huxley axonal model to analyze the effects of non-symmetric waveforms on conduction block of myelinated axons induced by high-frequency (10–300 kHz) biphasic electrical stimulation. The results predict a monotonic relationship between block threshold and stimulatio...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491630/ https://www.ncbi.nlm.nih.gov/pubmed/26217217 http://dx.doi.org/10.3389/fncom.2015.00086 |
_version_ | 1782379673219497984 |
---|---|
author | Zhao, Shouguo Yang, Guangning Wang, Jicheng Roppolo, James R. de Groat, William C. Tai, Changfeng |
author_facet | Zhao, Shouguo Yang, Guangning Wang, Jicheng Roppolo, James R. de Groat, William C. Tai, Changfeng |
author_sort | Zhao, Shouguo |
collection | PubMed |
description | This study used the Frankenhaeuser–Huxley axonal model to analyze the effects of non-symmetric waveforms on conduction block of myelinated axons induced by high-frequency (10–300 kHz) biphasic electrical stimulation. The results predict a monotonic relationship between block threshold and stimulation frequency for symmetric waveform and a non-monotonic relationship for non-symmetric waveforms. The symmetric waveform causes conduction block by constantly activating both sodium and potassium channels at frequencies of 20–300 kHz, while the non-symmetric waveforms share the same blocking mechanism from 20 kHz up to the peak threshold frequency. At the frequencies above the peak threshold frequency the non-symmetric waveforms block axonal conduction by either hyperpolarizing the membrane (if the positive pulse is longer) or depolarizing the membrane (if the negative pulse is longer). This simulation study further increases our understanding of conduction block in myelinated axons induced by high-frequency biphasic electrical stimulation, and can guide future animal experiments as well as optimize stimulation parameters that might be used for electrically induced nerve block in clinical applications. |
format | Online Article Text |
id | pubmed-4491630 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-44916302015-07-27 Conduction block in myelinated axons induced by high-frequency (kHz) non-symmetric biphasic stimulation Zhao, Shouguo Yang, Guangning Wang, Jicheng Roppolo, James R. de Groat, William C. Tai, Changfeng Front Comput Neurosci Neuroscience This study used the Frankenhaeuser–Huxley axonal model to analyze the effects of non-symmetric waveforms on conduction block of myelinated axons induced by high-frequency (10–300 kHz) biphasic electrical stimulation. The results predict a monotonic relationship between block threshold and stimulation frequency for symmetric waveform and a non-monotonic relationship for non-symmetric waveforms. The symmetric waveform causes conduction block by constantly activating both sodium and potassium channels at frequencies of 20–300 kHz, while the non-symmetric waveforms share the same blocking mechanism from 20 kHz up to the peak threshold frequency. At the frequencies above the peak threshold frequency the non-symmetric waveforms block axonal conduction by either hyperpolarizing the membrane (if the positive pulse is longer) or depolarizing the membrane (if the negative pulse is longer). This simulation study further increases our understanding of conduction block in myelinated axons induced by high-frequency biphasic electrical stimulation, and can guide future animal experiments as well as optimize stimulation parameters that might be used for electrically induced nerve block in clinical applications. Frontiers Media S.A. 2015-07-06 /pmc/articles/PMC4491630/ /pubmed/26217217 http://dx.doi.org/10.3389/fncom.2015.00086 Text en Copyright © 2015 Zhao, Yang, Wang, Roppolo, de Groat and Tai. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Zhao, Shouguo Yang, Guangning Wang, Jicheng Roppolo, James R. de Groat, William C. Tai, Changfeng Conduction block in myelinated axons induced by high-frequency (kHz) non-symmetric biphasic stimulation |
title | Conduction block in myelinated axons induced by high-frequency (kHz) non-symmetric biphasic stimulation |
title_full | Conduction block in myelinated axons induced by high-frequency (kHz) non-symmetric biphasic stimulation |
title_fullStr | Conduction block in myelinated axons induced by high-frequency (kHz) non-symmetric biphasic stimulation |
title_full_unstemmed | Conduction block in myelinated axons induced by high-frequency (kHz) non-symmetric biphasic stimulation |
title_short | Conduction block in myelinated axons induced by high-frequency (kHz) non-symmetric biphasic stimulation |
title_sort | conduction block in myelinated axons induced by high-frequency (khz) non-symmetric biphasic stimulation |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491630/ https://www.ncbi.nlm.nih.gov/pubmed/26217217 http://dx.doi.org/10.3389/fncom.2015.00086 |
work_keys_str_mv | AT zhaoshouguo conductionblockinmyelinatedaxonsinducedbyhighfrequencykhznonsymmetricbiphasicstimulation AT yangguangning conductionblockinmyelinatedaxonsinducedbyhighfrequencykhznonsymmetricbiphasicstimulation AT wangjicheng conductionblockinmyelinatedaxonsinducedbyhighfrequencykhznonsymmetricbiphasicstimulation AT roppolojamesr conductionblockinmyelinatedaxonsinducedbyhighfrequencykhznonsymmetricbiphasicstimulation AT degroatwilliamc conductionblockinmyelinatedaxonsinducedbyhighfrequencykhznonsymmetricbiphasicstimulation AT taichangfeng conductionblockinmyelinatedaxonsinducedbyhighfrequencykhznonsymmetricbiphasicstimulation |