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Profiling Invasiveness in Head and Neck Cancer: Recent Contributions of Genomic and Transcriptomic Approaches
High-throughput molecular profiling approaches have emerged as precious research tools in the field of head and neck translational oncology. Such approaches have identified and/or confirmed the role of several genes or pathways in the acquisition/maintenance of an invasive phenotype and the executio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491672/ https://www.ncbi.nlm.nih.gov/pubmed/25836654 http://dx.doi.org/10.3390/cancers7020585 |
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author | Nisa, Lluís Aebersold, Daniel Matthias Giger, Roland Caversaccio, Marco Domenico Borner, Urs Medová, Michaela Zimmer, Yitzhak |
author_facet | Nisa, Lluís Aebersold, Daniel Matthias Giger, Roland Caversaccio, Marco Domenico Borner, Urs Medová, Michaela Zimmer, Yitzhak |
author_sort | Nisa, Lluís |
collection | PubMed |
description | High-throughput molecular profiling approaches have emerged as precious research tools in the field of head and neck translational oncology. Such approaches have identified and/or confirmed the role of several genes or pathways in the acquisition/maintenance of an invasive phenotype and the execution of cellular programs related to cell invasion. Recently published new-generation sequencing studies in head and neck squamous cell carcinoma (HNSCC) have unveiled prominent roles in carcinogenesis and cell invasion of mutations involving NOTCH1 and PI3K-patwhay components. Gene-expression profiling studies combined with systems biology approaches have allowed identifying and gaining further mechanistic understanding into pathways commonly enriched in invasive HNSCC. These pathways include antigen-presenting and leucocyte adhesion molecules, as well as genes involved in cell-extracellular matrix interactions. Here we review the major insights into invasiveness in head and neck cancer provided by high-throughput molecular profiling approaches. |
format | Online Article Text |
id | pubmed-4491672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-44916722015-07-06 Profiling Invasiveness in Head and Neck Cancer: Recent Contributions of Genomic and Transcriptomic Approaches Nisa, Lluís Aebersold, Daniel Matthias Giger, Roland Caversaccio, Marco Domenico Borner, Urs Medová, Michaela Zimmer, Yitzhak Cancers (Basel) Review High-throughput molecular profiling approaches have emerged as precious research tools in the field of head and neck translational oncology. Such approaches have identified and/or confirmed the role of several genes or pathways in the acquisition/maintenance of an invasive phenotype and the execution of cellular programs related to cell invasion. Recently published new-generation sequencing studies in head and neck squamous cell carcinoma (HNSCC) have unveiled prominent roles in carcinogenesis and cell invasion of mutations involving NOTCH1 and PI3K-patwhay components. Gene-expression profiling studies combined with systems biology approaches have allowed identifying and gaining further mechanistic understanding into pathways commonly enriched in invasive HNSCC. These pathways include antigen-presenting and leucocyte adhesion molecules, as well as genes involved in cell-extracellular matrix interactions. Here we review the major insights into invasiveness in head and neck cancer provided by high-throughput molecular profiling approaches. MDPI 2015-03-31 /pmc/articles/PMC4491672/ /pubmed/25836654 http://dx.doi.org/10.3390/cancers7020585 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nisa, Lluís Aebersold, Daniel Matthias Giger, Roland Caversaccio, Marco Domenico Borner, Urs Medová, Michaela Zimmer, Yitzhak Profiling Invasiveness in Head and Neck Cancer: Recent Contributions of Genomic and Transcriptomic Approaches |
title | Profiling Invasiveness in Head and Neck Cancer: Recent Contributions of Genomic and Transcriptomic Approaches |
title_full | Profiling Invasiveness in Head and Neck Cancer: Recent Contributions of Genomic and Transcriptomic Approaches |
title_fullStr | Profiling Invasiveness in Head and Neck Cancer: Recent Contributions of Genomic and Transcriptomic Approaches |
title_full_unstemmed | Profiling Invasiveness in Head and Neck Cancer: Recent Contributions of Genomic and Transcriptomic Approaches |
title_short | Profiling Invasiveness in Head and Neck Cancer: Recent Contributions of Genomic and Transcriptomic Approaches |
title_sort | profiling invasiveness in head and neck cancer: recent contributions of genomic and transcriptomic approaches |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491672/ https://www.ncbi.nlm.nih.gov/pubmed/25836654 http://dx.doi.org/10.3390/cancers7020585 |
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