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A Possible Association between Melanoma and Prostate Cancer. Results from a Case-Control-Study

Melanoma and prostate cancer are the fifth and first most common cancers in men within the United States, respectively. The association between the two cancers lies in the mutual androgen-dependence. However, the relationship between prostate cancer history and melanoma development remains to be fur...

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Detalles Bibliográficos
Autores principales: Goldenberg, Alina, Jiang, Shang I. Brian, Cohen, Philip R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491677/
https://www.ncbi.nlm.nih.gov/pubmed/25884238
http://dx.doi.org/10.3390/cancers7020670
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author Goldenberg, Alina
Jiang, Shang I. Brian
Cohen, Philip R.
author_facet Goldenberg, Alina
Jiang, Shang I. Brian
Cohen, Philip R.
author_sort Goldenberg, Alina
collection PubMed
description Melanoma and prostate cancer are the fifth and first most common cancers in men within the United States, respectively. The association between the two cancers lies in the mutual androgen-dependence. However, the relationship between prostate cancer history and melanoma development remains to be further elucidated. We aim to determine the odds of history of prostate cancer among men with melanoma as compared to time-frame, clinic, and provider-matched controls without melanoma within a single academic surgical center. We present a case-control study comparing men treated for melanoma and non-melanoma cancer by a single provider between 2010 and 2014 within an academic dermatologic surgical center. Overall, there were nine cases of prostate cancer among the melanoma group and two cases amongst the controls—a statistically significant difference in both uni- and multivariable analyses (p = 0.057 [95% CI 1, 23.5], p = 0.042 [95% CI 1.1, 129], respectively). Body mass index, alcohol use, and skin type II were significant risk factors for melanoma (p = 0.011 [95% CI 1, 1.3], 0.005 [95% CI 1.4, 7], 0.025 [95% CI 1.1, 3.3], respectively). There were more immunosuppressed controls (p = 0.002); however, the melanoma patients had a significantly longer duration of immunosuppression (11.6 vs. 1.9 years, p < 0.001 [95% CI 0.03, 0.5]). Melanoma screenings for men should include questions on prostate cancer history. Prostate cancer patients may benefit from more frequent and comprehensive melanoma screening.
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spelling pubmed-44916772015-07-06 A Possible Association between Melanoma and Prostate Cancer. Results from a Case-Control-Study Goldenberg, Alina Jiang, Shang I. Brian Cohen, Philip R. Cancers (Basel) Article Melanoma and prostate cancer are the fifth and first most common cancers in men within the United States, respectively. The association between the two cancers lies in the mutual androgen-dependence. However, the relationship between prostate cancer history and melanoma development remains to be further elucidated. We aim to determine the odds of history of prostate cancer among men with melanoma as compared to time-frame, clinic, and provider-matched controls without melanoma within a single academic surgical center. We present a case-control study comparing men treated for melanoma and non-melanoma cancer by a single provider between 2010 and 2014 within an academic dermatologic surgical center. Overall, there were nine cases of prostate cancer among the melanoma group and two cases amongst the controls—a statistically significant difference in both uni- and multivariable analyses (p = 0.057 [95% CI 1, 23.5], p = 0.042 [95% CI 1.1, 129], respectively). Body mass index, alcohol use, and skin type II were significant risk factors for melanoma (p = 0.011 [95% CI 1, 1.3], 0.005 [95% CI 1.4, 7], 0.025 [95% CI 1.1, 3.3], respectively). There were more immunosuppressed controls (p = 0.002); however, the melanoma patients had a significantly longer duration of immunosuppression (11.6 vs. 1.9 years, p < 0.001 [95% CI 0.03, 0.5]). Melanoma screenings for men should include questions on prostate cancer history. Prostate cancer patients may benefit from more frequent and comprehensive melanoma screening. MDPI 2015-04-15 /pmc/articles/PMC4491677/ /pubmed/25884238 http://dx.doi.org/10.3390/cancers7020670 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Goldenberg, Alina
Jiang, Shang I. Brian
Cohen, Philip R.
A Possible Association between Melanoma and Prostate Cancer. Results from a Case-Control-Study
title A Possible Association between Melanoma and Prostate Cancer. Results from a Case-Control-Study
title_full A Possible Association between Melanoma and Prostate Cancer. Results from a Case-Control-Study
title_fullStr A Possible Association between Melanoma and Prostate Cancer. Results from a Case-Control-Study
title_full_unstemmed A Possible Association between Melanoma and Prostate Cancer. Results from a Case-Control-Study
title_short A Possible Association between Melanoma and Prostate Cancer. Results from a Case-Control-Study
title_sort possible association between melanoma and prostate cancer. results from a case-control-study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491677/
https://www.ncbi.nlm.nih.gov/pubmed/25884238
http://dx.doi.org/10.3390/cancers7020670
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