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Sarcoidosis in Melanoma Patients: Case Report and Literature Review

Sarcoidosis is a systemic inflammatory disease characterized by the development of noncaseating granulomas in multiple organ systems. Many hematologic malignancies and solid tumors, including melanoma, have been associated with sarcoidosis. We describe the clinical and pathologic findings of a 54-ye...

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Autores principales: Beutler, Bryce D., Cohen, Philip R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491696/
https://www.ncbi.nlm.nih.gov/pubmed/26083934
http://dx.doi.org/10.3390/cancers7020821
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author Beutler, Bryce D.
Cohen, Philip R.
author_facet Beutler, Bryce D.
Cohen, Philip R.
author_sort Beutler, Bryce D.
collection PubMed
description Sarcoidosis is a systemic inflammatory disease characterized by the development of noncaseating granulomas in multiple organ systems. Many hematologic malignancies and solid tumors, including melanoma, have been associated with sarcoidosis. We describe the clinical and pathologic findings of a 54-year-old man with melanoma-associated sarcoidosis. In addition, we not only review the literature describing characteristics of other melanoma patients with sarcoidosis, but also the features of melanoma patients with antineoplastic therapy-associated sarcoidosis. Sarcoidosis has been described in 80 melanoma patients; sufficient information for analysis was provided in 39 of these individuals. In 43.6% of individuals (17 out of 39), sarcoidosis was directly associated with melanoma; in 56.4% of oncologic patients (22 out of 39), sarcoidosis was induced by antineoplastic therapy that had been administered for the treatment of their metastatic melanoma. The discovery of melanoma preceded the development of sarcoidosis in 12 of the 17 (70.5%) individuals who did not receive systemic treatment. Pulmonary and/or cutaneous manifestations of sarcoidosis were common among both groups of patients. Most patients did not require treatment for sarcoidosis. Melanoma patients—either following antineoplastic therapy or without systemic treatment—may be at an increased risk to develop sarcoidosis. In antineoplastic therapy naive melanoma patients, a common etiologic factor—such as exposure to ultraviolet light—may play a role in their developing melanoma and sarcoidosis.
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spelling pubmed-44916962015-07-06 Sarcoidosis in Melanoma Patients: Case Report and Literature Review Beutler, Bryce D. Cohen, Philip R. Cancers (Basel) Review Sarcoidosis is a systemic inflammatory disease characterized by the development of noncaseating granulomas in multiple organ systems. Many hematologic malignancies and solid tumors, including melanoma, have been associated with sarcoidosis. We describe the clinical and pathologic findings of a 54-year-old man with melanoma-associated sarcoidosis. In addition, we not only review the literature describing characteristics of other melanoma patients with sarcoidosis, but also the features of melanoma patients with antineoplastic therapy-associated sarcoidosis. Sarcoidosis has been described in 80 melanoma patients; sufficient information for analysis was provided in 39 of these individuals. In 43.6% of individuals (17 out of 39), sarcoidosis was directly associated with melanoma; in 56.4% of oncologic patients (22 out of 39), sarcoidosis was induced by antineoplastic therapy that had been administered for the treatment of their metastatic melanoma. The discovery of melanoma preceded the development of sarcoidosis in 12 of the 17 (70.5%) individuals who did not receive systemic treatment. Pulmonary and/or cutaneous manifestations of sarcoidosis were common among both groups of patients. Most patients did not require treatment for sarcoidosis. Melanoma patients—either following antineoplastic therapy or without systemic treatment—may be at an increased risk to develop sarcoidosis. In antineoplastic therapy naive melanoma patients, a common etiologic factor—such as exposure to ultraviolet light—may play a role in their developing melanoma and sarcoidosis. MDPI 2015-06-15 /pmc/articles/PMC4491696/ /pubmed/26083934 http://dx.doi.org/10.3390/cancers7020821 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Beutler, Bryce D.
Cohen, Philip R.
Sarcoidosis in Melanoma Patients: Case Report and Literature Review
title Sarcoidosis in Melanoma Patients: Case Report and Literature Review
title_full Sarcoidosis in Melanoma Patients: Case Report and Literature Review
title_fullStr Sarcoidosis in Melanoma Patients: Case Report and Literature Review
title_full_unstemmed Sarcoidosis in Melanoma Patients: Case Report and Literature Review
title_short Sarcoidosis in Melanoma Patients: Case Report and Literature Review
title_sort sarcoidosis in melanoma patients: case report and literature review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491696/
https://www.ncbi.nlm.nih.gov/pubmed/26083934
http://dx.doi.org/10.3390/cancers7020821
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