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In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging
Cerenkov luminescence imaging utilizes visible photons emitted from radiopharmaceuticals to achieve in vivo optical molecular-derived signals. Since Cerenkov radiation is weak, non-optimum for tissue penetration and continuous regardless of biological interactions, it is challenging to detect this s...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491820/ https://www.ncbi.nlm.nih.gov/pubmed/26123615 http://dx.doi.org/10.1038/ncomms8560 |
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author | Hu, Zhenhua Qu, Yawei Wang, Kun Zhang, Xiaojun Zha, Jiali Song, Tianming Bao, Chengpeng Liu, Haixiao Wang, Zhongliang Wang, Jing Liu, Zhongyu Liu, Haifeng Tian, Jie |
author_facet | Hu, Zhenhua Qu, Yawei Wang, Kun Zhang, Xiaojun Zha, Jiali Song, Tianming Bao, Chengpeng Liu, Haixiao Wang, Zhongliang Wang, Jing Liu, Zhongyu Liu, Haifeng Tian, Jie |
author_sort | Hu, Zhenhua |
collection | PubMed |
description | Cerenkov luminescence imaging utilizes visible photons emitted from radiopharmaceuticals to achieve in vivo optical molecular-derived signals. Since Cerenkov radiation is weak, non-optimum for tissue penetration and continuous regardless of biological interactions, it is challenging to detect this signal with a diagnostic dose. Therefore, it is challenging to achieve useful activated optical imaging for the acquisition of direct molecular information. Here we introduce a novel imaging strategy, which converts γ and Cerenkov radiation from radioisotopes into fluorescence through europium oxide nanoparticles. After a series of imaging studies, we demonstrate that this approach provides strong optical signals with high signal-to-background ratios, an ideal tissue penetration spectrum and activatable imaging ability. In comparison with present imaging techniques, it detects tumour lesions with low radioactive tracer uptake or small tumour lesions more effectively. We believe it will facilitate the development of nuclear and optical molecular imaging for new, highly sensitive imaging applications. |
format | Online Article Text |
id | pubmed-4491820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44918202015-07-08 In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging Hu, Zhenhua Qu, Yawei Wang, Kun Zhang, Xiaojun Zha, Jiali Song, Tianming Bao, Chengpeng Liu, Haixiao Wang, Zhongliang Wang, Jing Liu, Zhongyu Liu, Haifeng Tian, Jie Nat Commun Article Cerenkov luminescence imaging utilizes visible photons emitted from radiopharmaceuticals to achieve in vivo optical molecular-derived signals. Since Cerenkov radiation is weak, non-optimum for tissue penetration and continuous regardless of biological interactions, it is challenging to detect this signal with a diagnostic dose. Therefore, it is challenging to achieve useful activated optical imaging for the acquisition of direct molecular information. Here we introduce a novel imaging strategy, which converts γ and Cerenkov radiation from radioisotopes into fluorescence through europium oxide nanoparticles. After a series of imaging studies, we demonstrate that this approach provides strong optical signals with high signal-to-background ratios, an ideal tissue penetration spectrum and activatable imaging ability. In comparison with present imaging techniques, it detects tumour lesions with low radioactive tracer uptake or small tumour lesions more effectively. We believe it will facilitate the development of nuclear and optical molecular imaging for new, highly sensitive imaging applications. Nature Pub. Group 2015-06-30 /pmc/articles/PMC4491820/ /pubmed/26123615 http://dx.doi.org/10.1038/ncomms8560 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Hu, Zhenhua Qu, Yawei Wang, Kun Zhang, Xiaojun Zha, Jiali Song, Tianming Bao, Chengpeng Liu, Haixiao Wang, Zhongliang Wang, Jing Liu, Zhongyu Liu, Haifeng Tian, Jie In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging |
title | In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging |
title_full | In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging |
title_fullStr | In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging |
title_full_unstemmed | In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging |
title_short | In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging |
title_sort | in vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491820/ https://www.ncbi.nlm.nih.gov/pubmed/26123615 http://dx.doi.org/10.1038/ncomms8560 |
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