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Tulane virus recognizes sialic acids as cellular receptors

The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying virus-host interactions during calicivirus infection. HuNoVs remain difficult to study due to the lack of an effective cell cultu...

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Autores principales: Tan, Ming, Wei, Chao, Huang, Pengwei, Fan, Qiang, Quigley, Christina, Xia, Ming, Fang, Hao, Zhang, Xufu, Zhong, Weiming, Klassen, John S., Jiang, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491846/
https://www.ncbi.nlm.nih.gov/pubmed/26146020
http://dx.doi.org/10.1038/srep11784
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author Tan, Ming
Wei, Chao
Huang, Pengwei
Fan, Qiang
Quigley, Christina
Xia, Ming
Fang, Hao
Zhang, Xufu
Zhong, Weiming
Klassen, John S.
Jiang, Xi
author_facet Tan, Ming
Wei, Chao
Huang, Pengwei
Fan, Qiang
Quigley, Christina
Xia, Ming
Fang, Hao
Zhang, Xufu
Zhong, Weiming
Klassen, John S.
Jiang, Xi
author_sort Tan, Ming
collection PubMed
description The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying virus-host interactions during calicivirus infection. HuNoVs remain difficult to study due to the lack of an effective cell culture model. In this study, we demonstrated that Tulane virus (TV), a cultivable primate calicivirus, also recognizes SAs in addition to the previously known TV-HBGA interactions. Evidence supporting this discovery includes that TV virions bound synthetic sialoglycoconjugates (SGCs) and that treatment of TV permissive LLC-MK2 cells with either neuraminidases or SA-binding lectins inhibited TV infectivity. In addition, we found that Maackia amurensis leukoagglutinin (MAL), a lectin that recognizes the α-2,3 linked SAs, bound LLC-MK2 cells, as well as TV, by which MAL promoted TV infectivity in cell culture. Our findings further highlight TV as a valuable surrogate for huNoVs, particularly in studying virus-host interactions that may involve two host carbohydrate receptors or co-receptors for infection.
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spelling pubmed-44918462015-07-08 Tulane virus recognizes sialic acids as cellular receptors Tan, Ming Wei, Chao Huang, Pengwei Fan, Qiang Quigley, Christina Xia, Ming Fang, Hao Zhang, Xufu Zhong, Weiming Klassen, John S. Jiang, Xi Sci Rep Article The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying virus-host interactions during calicivirus infection. HuNoVs remain difficult to study due to the lack of an effective cell culture model. In this study, we demonstrated that Tulane virus (TV), a cultivable primate calicivirus, also recognizes SAs in addition to the previously known TV-HBGA interactions. Evidence supporting this discovery includes that TV virions bound synthetic sialoglycoconjugates (SGCs) and that treatment of TV permissive LLC-MK2 cells with either neuraminidases or SA-binding lectins inhibited TV infectivity. In addition, we found that Maackia amurensis leukoagglutinin (MAL), a lectin that recognizes the α-2,3 linked SAs, bound LLC-MK2 cells, as well as TV, by which MAL promoted TV infectivity in cell culture. Our findings further highlight TV as a valuable surrogate for huNoVs, particularly in studying virus-host interactions that may involve two host carbohydrate receptors or co-receptors for infection. Nature Publishing Group 2015-07-06 /pmc/articles/PMC4491846/ /pubmed/26146020 http://dx.doi.org/10.1038/srep11784 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Tan, Ming
Wei, Chao
Huang, Pengwei
Fan, Qiang
Quigley, Christina
Xia, Ming
Fang, Hao
Zhang, Xufu
Zhong, Weiming
Klassen, John S.
Jiang, Xi
Tulane virus recognizes sialic acids as cellular receptors
title Tulane virus recognizes sialic acids as cellular receptors
title_full Tulane virus recognizes sialic acids as cellular receptors
title_fullStr Tulane virus recognizes sialic acids as cellular receptors
title_full_unstemmed Tulane virus recognizes sialic acids as cellular receptors
title_short Tulane virus recognizes sialic acids as cellular receptors
title_sort tulane virus recognizes sialic acids as cellular receptors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491846/
https://www.ncbi.nlm.nih.gov/pubmed/26146020
http://dx.doi.org/10.1038/srep11784
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