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Tulane virus recognizes sialic acids as cellular receptors
The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying virus-host interactions during calicivirus infection. HuNoVs remain difficult to study due to the lack of an effective cell cultu...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491846/ https://www.ncbi.nlm.nih.gov/pubmed/26146020 http://dx.doi.org/10.1038/srep11784 |
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author | Tan, Ming Wei, Chao Huang, Pengwei Fan, Qiang Quigley, Christina Xia, Ming Fang, Hao Zhang, Xufu Zhong, Weiming Klassen, John S. Jiang, Xi |
author_facet | Tan, Ming Wei, Chao Huang, Pengwei Fan, Qiang Quigley, Christina Xia, Ming Fang, Hao Zhang, Xufu Zhong, Weiming Klassen, John S. Jiang, Xi |
author_sort | Tan, Ming |
collection | PubMed |
description | The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying virus-host interactions during calicivirus infection. HuNoVs remain difficult to study due to the lack of an effective cell culture model. In this study, we demonstrated that Tulane virus (TV), a cultivable primate calicivirus, also recognizes SAs in addition to the previously known TV-HBGA interactions. Evidence supporting this discovery includes that TV virions bound synthetic sialoglycoconjugates (SGCs) and that treatment of TV permissive LLC-MK2 cells with either neuraminidases or SA-binding lectins inhibited TV infectivity. In addition, we found that Maackia amurensis leukoagglutinin (MAL), a lectin that recognizes the α-2,3 linked SAs, bound LLC-MK2 cells, as well as TV, by which MAL promoted TV infectivity in cell culture. Our findings further highlight TV as a valuable surrogate for huNoVs, particularly in studying virus-host interactions that may involve two host carbohydrate receptors or co-receptors for infection. |
format | Online Article Text |
id | pubmed-4491846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44918462015-07-08 Tulane virus recognizes sialic acids as cellular receptors Tan, Ming Wei, Chao Huang, Pengwei Fan, Qiang Quigley, Christina Xia, Ming Fang, Hao Zhang, Xufu Zhong, Weiming Klassen, John S. Jiang, Xi Sci Rep Article The recent discovery that human noroviruses (huNoVs) recognize sialic acids (SAs) in addition to histo-blood group antigens (HBGAs) pointed to a new direction in studying virus-host interactions during calicivirus infection. HuNoVs remain difficult to study due to the lack of an effective cell culture model. In this study, we demonstrated that Tulane virus (TV), a cultivable primate calicivirus, also recognizes SAs in addition to the previously known TV-HBGA interactions. Evidence supporting this discovery includes that TV virions bound synthetic sialoglycoconjugates (SGCs) and that treatment of TV permissive LLC-MK2 cells with either neuraminidases or SA-binding lectins inhibited TV infectivity. In addition, we found that Maackia amurensis leukoagglutinin (MAL), a lectin that recognizes the α-2,3 linked SAs, bound LLC-MK2 cells, as well as TV, by which MAL promoted TV infectivity in cell culture. Our findings further highlight TV as a valuable surrogate for huNoVs, particularly in studying virus-host interactions that may involve two host carbohydrate receptors or co-receptors for infection. Nature Publishing Group 2015-07-06 /pmc/articles/PMC4491846/ /pubmed/26146020 http://dx.doi.org/10.1038/srep11784 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Tan, Ming Wei, Chao Huang, Pengwei Fan, Qiang Quigley, Christina Xia, Ming Fang, Hao Zhang, Xufu Zhong, Weiming Klassen, John S. Jiang, Xi Tulane virus recognizes sialic acids as cellular receptors |
title | Tulane virus recognizes sialic acids as cellular receptors |
title_full | Tulane virus recognizes sialic acids as cellular receptors |
title_fullStr | Tulane virus recognizes sialic acids as cellular receptors |
title_full_unstemmed | Tulane virus recognizes sialic acids as cellular receptors |
title_short | Tulane virus recognizes sialic acids as cellular receptors |
title_sort | tulane virus recognizes sialic acids as cellular receptors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491846/ https://www.ncbi.nlm.nih.gov/pubmed/26146020 http://dx.doi.org/10.1038/srep11784 |
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