Balancing the Expression and Production of a Heterodimeric Protein: Recombinant Agkisacutacin as a Novel Antithrombotic Drug Candidate

Agkisacucetin extracted from the venom of Agkistrodon acutus has been demonstrated to be a promising antithrombotic drug candidate in clinical studies due to its function as a novel platelet membrane glycoprotein (GP) Ib inhibitor. Agkisacucetin is a heterodimeric protein composed of α- and β-subuni...

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Detalles Bibliográficos
Autores principales: Guo, Yugang, Wu, Jing, Jia, Hao, Chen, Wei, Shao, Changsheng, Zhao, Lei, Ma, Jiajia, Li, Rui, Zhong, Yongjun, Fang, Fang, Wang, Dong, Sun, Jie, Qian, Fang, Dai, Xiangrong, Zhang, Guohui, Tian, Zhigang, Xiaoyi Li, Benjamin, Xiao, Weihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491848/
https://www.ncbi.nlm.nih.gov/pubmed/26144864
http://dx.doi.org/10.1038/srep11730

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