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Exploring genetic markers of adult obesity risk in black adolescent South Africans—the Birth to Twenty Cohort
To date more than 90 loci that show an association with body mass index (BMI) and other obesity-related traits, have been discovered through genome-wide association studies. These findings have been widely replicated, mostly in European and Asian populations, but systematic investigation in African...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491859/ https://www.ncbi.nlm.nih.gov/pubmed/26075635 http://dx.doi.org/10.1038/nutd.2015.7 |
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author | Pillay, V Crowther, N J Ramsay, M Smith, G D Norris, S A Lombard, Z |
author_facet | Pillay, V Crowther, N J Ramsay, M Smith, G D Norris, S A Lombard, Z |
author_sort | Pillay, V |
collection | PubMed |
description | To date more than 90 loci that show an association with body mass index (BMI) and other obesity-related traits, have been discovered through genome-wide association studies. These findings have been widely replicated, mostly in European and Asian populations, but systematic investigation in African cohorts is still lacking. Therefore, the aim of our study was to replicate the association of six single-nucleotide polymorphisms (SNPs) previously linked to BMI, in a South African black adolescent cohort. The SNPs were in or near GNPDA2 (rs10938397), MTCH2 (rs10838738), NEGR1 (rs2568958), SH2B1 (rs7498665), STK33 (rs10769908) and TMEM18 (rs6548238). The SNPs were genotyped in 990 adolescents from the Birth to Twenty study, using an Illumina VeraCode assay, and association with BMI statistically assesed by using PLINK. Three of the SNPs tested were associated with BMI in this African cohort, and showed a consistent (albeit smaller) directional effect to that observed in non-African cohorts. We identified significant association between BMI and rs10938397 (effect allele-G) near GNPDA2 (P(adj)=0.003), rs7498665 (effect allele-G) in SH2B1 (P(adj)=0.014) and rs6548238 (effect allele-C) near TMEM18 (P(adj)=0.030). This data suggests that common genetic variants potentially contributes to obesity risk in diverse population groups. |
format | Online Article Text |
id | pubmed-4491859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44918592015-07-06 Exploring genetic markers of adult obesity risk in black adolescent South Africans—the Birth to Twenty Cohort Pillay, V Crowther, N J Ramsay, M Smith, G D Norris, S A Lombard, Z Nutr Diabetes Short Communication To date more than 90 loci that show an association with body mass index (BMI) and other obesity-related traits, have been discovered through genome-wide association studies. These findings have been widely replicated, mostly in European and Asian populations, but systematic investigation in African cohorts is still lacking. Therefore, the aim of our study was to replicate the association of six single-nucleotide polymorphisms (SNPs) previously linked to BMI, in a South African black adolescent cohort. The SNPs were in or near GNPDA2 (rs10938397), MTCH2 (rs10838738), NEGR1 (rs2568958), SH2B1 (rs7498665), STK33 (rs10769908) and TMEM18 (rs6548238). The SNPs were genotyped in 990 adolescents from the Birth to Twenty study, using an Illumina VeraCode assay, and association with BMI statistically assesed by using PLINK. Three of the SNPs tested were associated with BMI in this African cohort, and showed a consistent (albeit smaller) directional effect to that observed in non-African cohorts. We identified significant association between BMI and rs10938397 (effect allele-G) near GNPDA2 (P(adj)=0.003), rs7498665 (effect allele-G) in SH2B1 (P(adj)=0.014) and rs6548238 (effect allele-C) near TMEM18 (P(adj)=0.030). This data suggests that common genetic variants potentially contributes to obesity risk in diverse population groups. Nature Publishing Group 2015-06 2015-06-15 /pmc/articles/PMC4491859/ /pubmed/26075635 http://dx.doi.org/10.1038/nutd.2015.7 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Short Communication Pillay, V Crowther, N J Ramsay, M Smith, G D Norris, S A Lombard, Z Exploring genetic markers of adult obesity risk in black adolescent South Africans—the Birth to Twenty Cohort |
title | Exploring genetic markers of adult obesity risk in black adolescent South Africans—the Birth to Twenty Cohort |
title_full | Exploring genetic markers of adult obesity risk in black adolescent South Africans—the Birth to Twenty Cohort |
title_fullStr | Exploring genetic markers of adult obesity risk in black adolescent South Africans—the Birth to Twenty Cohort |
title_full_unstemmed | Exploring genetic markers of adult obesity risk in black adolescent South Africans—the Birth to Twenty Cohort |
title_short | Exploring genetic markers of adult obesity risk in black adolescent South Africans—the Birth to Twenty Cohort |
title_sort | exploring genetic markers of adult obesity risk in black adolescent south africans—the birth to twenty cohort |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491859/ https://www.ncbi.nlm.nih.gov/pubmed/26075635 http://dx.doi.org/10.1038/nutd.2015.7 |
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