NetworkPainter: dynamic intracellular pathway animation in Cytobank

BACKGROUND: High-throughput technologies such as flow and mass cytometry have the potential to illuminate cellular networks. However, analyzing the data produced by these technologies is challenging. Visualization is needed to help researchers explore this data. RESULTS: We developed a web-based sof...

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Detalles Bibliográficos
Autores principales: Karr, Jonathan R, Guturu, Harendra, Chen, Edward Y, Blair, Stuart L, Irish, Jonathan M, Kotecha, Nikesh, Covert, Markus W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491883/
https://www.ncbi.nlm.nih.gov/pubmed/26003204
http://dx.doi.org/10.1186/s12859-015-0602-4
Descripción
Sumario:BACKGROUND: High-throughput technologies such as flow and mass cytometry have the potential to illuminate cellular networks. However, analyzing the data produced by these technologies is challenging. Visualization is needed to help researchers explore this data. RESULTS: We developed a web-based software program, NetworkPainter, to enable researchers to analyze dynamic cytometry data in the context of pathway diagrams. NetworkPainter provides researchers a graphical interface to draw and “paint” pathway diagrams with experimental data, producing animated diagrams which display the activity of each network node at each time point. CONCLUSION: NetworkPainter enables researchers to more fully explore multi-parameter, dynamical cytometry data. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12859-015-0602-4) contains supplementary material, which is available to authorized users.

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