NetworkPainter: dynamic intracellular pathway animation in Cytobank

BACKGROUND: High-throughput technologies such as flow and mass cytometry have the potential to illuminate cellular networks. However, analyzing the data produced by these technologies is challenging. Visualization is needed to help researchers explore this data. RESULTS: We developed a web-based sof...

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Autores principales: Karr, Jonathan R, Guturu, Harendra, Chen, Edward Y, Blair, Stuart L, Irish, Jonathan M, Kotecha, Nikesh, Covert, Markus W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Software
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491883/
https://www.ncbi.nlm.nih.gov/pubmed/26003204
http://dx.doi.org/10.1186/s12859-015-0602-4
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author Karr, Jonathan R
Guturu, Harendra
Chen, Edward Y
Blair, Stuart L
Irish, Jonathan M
Kotecha, Nikesh
Covert, Markus W
author_facet Karr, Jonathan R
Guturu, Harendra
Chen, Edward Y
Blair, Stuart L
Irish, Jonathan M
Kotecha, Nikesh
Covert, Markus W
author_sort Karr, Jonathan R
collection PubMed
description BACKGROUND: High-throughput technologies such as flow and mass cytometry have the potential to illuminate cellular networks. However, analyzing the data produced by these technologies is challenging. Visualization is needed to help researchers explore this data. RESULTS: We developed a web-based software program, NetworkPainter, to enable researchers to analyze dynamic cytometry data in the context of pathway diagrams. NetworkPainter provides researchers a graphical interface to draw and “paint” pathway diagrams with experimental data, producing animated diagrams which display the activity of each network node at each time point. CONCLUSION: NetworkPainter enables researchers to more fully explore multi-parameter, dynamical cytometry data. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12859-015-0602-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-44918832015-07-07 NetworkPainter: dynamic intracellular pathway animation in Cytobank Karr, Jonathan R Guturu, Harendra Chen, Edward Y Blair, Stuart L Irish, Jonathan M Kotecha, Nikesh Covert, Markus W BMC Bioinformatics Software BACKGROUND: High-throughput technologies such as flow and mass cytometry have the potential to illuminate cellular networks. However, analyzing the data produced by these technologies is challenging. Visualization is needed to help researchers explore this data. RESULTS: We developed a web-based software program, NetworkPainter, to enable researchers to analyze dynamic cytometry data in the context of pathway diagrams. NetworkPainter provides researchers a graphical interface to draw and “paint” pathway diagrams with experimental data, producing animated diagrams which display the activity of each network node at each time point. CONCLUSION: NetworkPainter enables researchers to more fully explore multi-parameter, dynamical cytometry data. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12859-015-0602-4) contains supplementary material, which is available to authorized users. BioMed Central 2015-05-25 /pmc/articles/PMC4491883/ /pubmed/26003204 http://dx.doi.org/10.1186/s12859-015-0602-4 Text en © Karr et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Software
Karr, Jonathan R
Guturu, Harendra
Chen, Edward Y
Blair, Stuart L
Irish, Jonathan M
Kotecha, Nikesh
Covert, Markus W
NetworkPainter: dynamic intracellular pathway animation in Cytobank
title NetworkPainter: dynamic intracellular pathway animation in Cytobank
title_full NetworkPainter: dynamic intracellular pathway animation in Cytobank
title_fullStr NetworkPainter: dynamic intracellular pathway animation in Cytobank
title_full_unstemmed NetworkPainter: dynamic intracellular pathway animation in Cytobank
title_short NetworkPainter: dynamic intracellular pathway animation in Cytobank
title_sort networkpainter: dynamic intracellular pathway animation in cytobank
topic Software
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491883/
https://www.ncbi.nlm.nih.gov/pubmed/26003204
http://dx.doi.org/10.1186/s12859-015-0602-4
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