Cargando…

Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.)

BACKGROUND: Disorders like hyperacidity and gastric ulcers are found very frequently now days because of a faulty lifestyle. Starches (Satwa) obtained from the rhizomes of two plants namely, Curcuma angustifolia Roxb. (Fam. Zingiberaceae) and Maranta arundinacea Linn. (Fam. Marantaceae) are used in...

Descripción completa

Detalles Bibliográficos
Autores principales: Rajashekhara, N., Ashok, B.K., Sharma, Parmeshwar P., Ravishankar, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492030/
https://www.ncbi.nlm.nih.gov/pubmed/26195908
http://dx.doi.org/10.4103/0974-8520.159013
_version_ 1782379725200556032
author Rajashekhara, N.
Ashok, B.K.
Sharma, Parmeshwar P.
Ravishankar, B.
author_facet Rajashekhara, N.
Ashok, B.K.
Sharma, Parmeshwar P.
Ravishankar, B.
author_sort Rajashekhara, N.
collection PubMed
description BACKGROUND: Disorders like hyperacidity and gastric ulcers are found very frequently now days because of a faulty lifestyle. Starches (Satwa) obtained from the rhizomes of two plants namely, Curcuma angustifolia Roxb. (Fam. Zingiberaceae) and Maranta arundinacea Linn. (Fam. Marantaceae) are used in folklore practice, as Tugaksheeree, for the treatment of the above-mentioned complaints. AIM: To assess the acute toxicity potential of the C. angustifolia and M. arundinacea along with their assessment for adaptogenic activity, by noting their effect on forced swimming-induced hypothermia and gastric ulceration in rats. MATERIALS AND METHODS: For acute toxicity study, the effect of test drugs C. angustifolia and M. arundinacea rhizome starch were studied after a single administration of up to three dose levels, with 4400 mg/kg as the maximum dose. The animals were observed for 72 hours periodically and mortality was recorded up to seven days. The adaptogenic and anti-ulcer activities were assessed by determining and comparing the changes in rectal temperature, ponderal changes, ulcer index and histopathological parameters in the test drug group with that of stress control group. RESULTS: Both the drugs did not produce any toxic symptoms or mortality even up to the maximum dose level of 4400 mg/kg. Both the test drugs significantly reversed the stress-induced gastric ulceration in comparison to stress-control rats. Starch from rhizome of C. angustifolia reversed forced swimming-induced hypothermia apparently, but not to a significant extent. However, the reversal of hypothermia found statistically significant in the rhizome starch of the M. arundinacea treated group. CONCLUSION: M. arundinacea had better anti-stress activity in comparision to C. angustifolia.
format Online
Article
Text
id pubmed-4492030
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-44920302015-07-20 Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.) Rajashekhara, N. Ashok, B.K. Sharma, Parmeshwar P. Ravishankar, B. Ayu Pharmacological Study BACKGROUND: Disorders like hyperacidity and gastric ulcers are found very frequently now days because of a faulty lifestyle. Starches (Satwa) obtained from the rhizomes of two plants namely, Curcuma angustifolia Roxb. (Fam. Zingiberaceae) and Maranta arundinacea Linn. (Fam. Marantaceae) are used in folklore practice, as Tugaksheeree, for the treatment of the above-mentioned complaints. AIM: To assess the acute toxicity potential of the C. angustifolia and M. arundinacea along with their assessment for adaptogenic activity, by noting their effect on forced swimming-induced hypothermia and gastric ulceration in rats. MATERIALS AND METHODS: For acute toxicity study, the effect of test drugs C. angustifolia and M. arundinacea rhizome starch were studied after a single administration of up to three dose levels, with 4400 mg/kg as the maximum dose. The animals were observed for 72 hours periodically and mortality was recorded up to seven days. The adaptogenic and anti-ulcer activities were assessed by determining and comparing the changes in rectal temperature, ponderal changes, ulcer index and histopathological parameters in the test drug group with that of stress control group. RESULTS: Both the drugs did not produce any toxic symptoms or mortality even up to the maximum dose level of 4400 mg/kg. Both the test drugs significantly reversed the stress-induced gastric ulceration in comparison to stress-control rats. Starch from rhizome of C. angustifolia reversed forced swimming-induced hypothermia apparently, but not to a significant extent. However, the reversal of hypothermia found statistically significant in the rhizome starch of the M. arundinacea treated group. CONCLUSION: M. arundinacea had better anti-stress activity in comparision to C. angustifolia. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4492030/ /pubmed/26195908 http://dx.doi.org/10.4103/0974-8520.159013 Text en Copyright: © AYU (An International Quarterly Journal of Research in Ayurveda) http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Pharmacological Study
Rajashekhara, N.
Ashok, B.K.
Sharma, Parmeshwar P.
Ravishankar, B.
Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.)
title Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.)
title_full Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.)
title_fullStr Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.)
title_full_unstemmed Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.)
title_short Evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of Tugaksheeree (Curcuma angustifolia Roxb. and Maranta arundinacea Linn.)
title_sort evaluation of acute toxicity and anti-ulcerogenic study of rhizome starch of two source plants of tugaksheeree (curcuma angustifolia roxb. and maranta arundinacea linn.)
topic Pharmacological Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492030/
https://www.ncbi.nlm.nih.gov/pubmed/26195908
http://dx.doi.org/10.4103/0974-8520.159013
work_keys_str_mv AT rajashekharan evaluationofacutetoxicityandantiulcerogenicstudyofrhizomestarchoftwosourceplantsoftugaksheereecurcumaangustifoliaroxbandmarantaarundinacealinn
AT ashokbk evaluationofacutetoxicityandantiulcerogenicstudyofrhizomestarchoftwosourceplantsoftugaksheereecurcumaangustifoliaroxbandmarantaarundinacealinn
AT sharmaparmeshwarp evaluationofacutetoxicityandantiulcerogenicstudyofrhizomestarchoftwosourceplantsoftugaksheereecurcumaangustifoliaroxbandmarantaarundinacealinn
AT ravishankarb evaluationofacutetoxicityandantiulcerogenicstudyofrhizomestarchoftwosourceplantsoftugaksheereecurcumaangustifoliaroxbandmarantaarundinacealinn