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Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children’s Environmental Health (MOCEH) Study

BACKGROUND: Manganese is an essential trace element and common component of water, soil, and air. Prenatal manganese exposure may affect fetal and infantile neurodevelopment, but reports on in utero manganese exposure and infant neurodevelopment are rare. OBJECTIVE: This study was conducted to inves...

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Autores principales: Chung, Soo Eun, Cheong, Hae-Kwan, Ha, Eun-Hee, Kim, Boong-Nyun, Ha, Mina, Kim, Yangho, Hong, Yun-Chul, Park, Hyesook, Oh, Se-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: NLM-Export 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492260/
https://www.ncbi.nlm.nih.gov/pubmed/25734517
http://dx.doi.org/10.1289/ehp.1307865
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author Chung, Soo Eun
Cheong, Hae-Kwan
Ha, Eun-Hee
Kim, Boong-Nyun
Ha, Mina
Kim, Yangho
Hong, Yun-Chul
Park, Hyesook
Oh, Se-Young
author_facet Chung, Soo Eun
Cheong, Hae-Kwan
Ha, Eun-Hee
Kim, Boong-Nyun
Ha, Mina
Kim, Yangho
Hong, Yun-Chul
Park, Hyesook
Oh, Se-Young
author_sort Chung, Soo Eun
collection PubMed
description BACKGROUND: Manganese is an essential trace element and common component of water, soil, and air. Prenatal manganese exposure may affect fetal and infantile neurodevelopment, but reports on in utero manganese exposure and infant neurodevelopment are rare. OBJECTIVE: This study was conducted to investigate a relationship between maternal blood manganese level and neurodevelopment of infants at 6 months of age. METHODS: Data were obtained from the Mothers and Children’s Environmental Health (MOCEH) birth cohort study. The study population included 232 pairs of pregnant women and their infants at 6 months of age. Maternal blood manganese was measured at term, just before delivery. Mental and psychomotor development in infancy was assessed at 6 months of age using the Bayley Scales of Infant Development. The relationship between maternal blood manganese level and the mental and psychomotor development indexes (MDI and PDI) was estimated for manganese modeled as a linear and as a categorical variable and using penalized splines for nonlinear modeling. RESULTS: Mean ± SD maternal blood manganese concentration was 22.5 ± 6.5 μg/L. After adjustment for potential confounders, blood manganese was used as a continuous variable in a linear and nonlinear model. Associations between maternal blood manganese and MDI and PDI scores followed an inverted U-shape dose–response curve after adjustment for potential confounders, with lower scores associated with both low and high blood concentrations [MDI: likelihood-ratio test (LRT) p = 0.075, PDI: LRT p = 0.038]. Associations of both outcomes with increasing blood manganese shifted from positive to negative at concentrations of 24–28 μg/L in this cohort of term, normal birth weight children. CONCLUSION: Although no cut-off point has been established to define manganese toxicity, both high and low blood manganese levels may be associated with neurobehavioral function in infants. CITATION: Chung SE, Cheong HK, Ha EH, Kim BN, Ha M, Kim Y, Hong YC, Park H, Oh SY. 2015. Maternal blood manganese and early neurodevelopment: the Mothers and Children’s Environmental Health (MOCEH) study. Environ Health Perspect 123:717–722; http://dx.doi.org/10.1289/ehp.1307865
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spelling pubmed-44922602015-07-09 Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children’s Environmental Health (MOCEH) Study Chung, Soo Eun Cheong, Hae-Kwan Ha, Eun-Hee Kim, Boong-Nyun Ha, Mina Kim, Yangho Hong, Yun-Chul Park, Hyesook Oh, Se-Young Environ Health Perspect Children's Health BACKGROUND: Manganese is an essential trace element and common component of water, soil, and air. Prenatal manganese exposure may affect fetal and infantile neurodevelopment, but reports on in utero manganese exposure and infant neurodevelopment are rare. OBJECTIVE: This study was conducted to investigate a relationship between maternal blood manganese level and neurodevelopment of infants at 6 months of age. METHODS: Data were obtained from the Mothers and Children’s Environmental Health (MOCEH) birth cohort study. The study population included 232 pairs of pregnant women and their infants at 6 months of age. Maternal blood manganese was measured at term, just before delivery. Mental and psychomotor development in infancy was assessed at 6 months of age using the Bayley Scales of Infant Development. The relationship between maternal blood manganese level and the mental and psychomotor development indexes (MDI and PDI) was estimated for manganese modeled as a linear and as a categorical variable and using penalized splines for nonlinear modeling. RESULTS: Mean ± SD maternal blood manganese concentration was 22.5 ± 6.5 μg/L. After adjustment for potential confounders, blood manganese was used as a continuous variable in a linear and nonlinear model. Associations between maternal blood manganese and MDI and PDI scores followed an inverted U-shape dose–response curve after adjustment for potential confounders, with lower scores associated with both low and high blood concentrations [MDI: likelihood-ratio test (LRT) p = 0.075, PDI: LRT p = 0.038]. Associations of both outcomes with increasing blood manganese shifted from positive to negative at concentrations of 24–28 μg/L in this cohort of term, normal birth weight children. CONCLUSION: Although no cut-off point has been established to define manganese toxicity, both high and low blood manganese levels may be associated with neurobehavioral function in infants. CITATION: Chung SE, Cheong HK, Ha EH, Kim BN, Ha M, Kim Y, Hong YC, Park H, Oh SY. 2015. Maternal blood manganese and early neurodevelopment: the Mothers and Children’s Environmental Health (MOCEH) study. Environ Health Perspect 123:717–722; http://dx.doi.org/10.1289/ehp.1307865 NLM-Export 2015-03-03 2015-07 /pmc/articles/PMC4492260/ /pubmed/25734517 http://dx.doi.org/10.1289/ehp.1307865 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Children's Health
Chung, Soo Eun
Cheong, Hae-Kwan
Ha, Eun-Hee
Kim, Boong-Nyun
Ha, Mina
Kim, Yangho
Hong, Yun-Chul
Park, Hyesook
Oh, Se-Young
Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children’s Environmental Health (MOCEH) Study
title Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children’s Environmental Health (MOCEH) Study
title_full Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children’s Environmental Health (MOCEH) Study
title_fullStr Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children’s Environmental Health (MOCEH) Study
title_full_unstemmed Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children’s Environmental Health (MOCEH) Study
title_short Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children’s Environmental Health (MOCEH) Study
title_sort maternal blood manganese and early neurodevelopment: the mothers and children’s environmental health (moceh) study
topic Children's Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492260/
https://www.ncbi.nlm.nih.gov/pubmed/25734517
http://dx.doi.org/10.1289/ehp.1307865
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