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Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington’s disease rats

Huntington’s disease is a chronic neurodegenerative disorder inherited in an autosomal dominant fashion, and characterized as involuntary movement. Quinolinic acid has been used to produce an animal model of Huntington’s disease. In the present study, the effect of treadmill exercise on spatial-lear...

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Autores principales: Ji, Eun-Sang, Kim, You-Mi, Shin, Mal-Soon, Kim, Chang-Ju, Lee, Kwang-Sik, Kim, Kijeong, Ha, Jonglin, Chung, Yong-Rak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Exercise Rehabilitation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492422/
https://www.ncbi.nlm.nih.gov/pubmed/26171378
http://dx.doi.org/10.12965/jer.150212
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author Ji, Eun-Sang
Kim, You-Mi
Shin, Mal-Soon
Kim, Chang-Ju
Lee, Kwang-Sik
Kim, Kijeong
Ha, Jonglin
Chung, Yong-Rak
author_facet Ji, Eun-Sang
Kim, You-Mi
Shin, Mal-Soon
Kim, Chang-Ju
Lee, Kwang-Sik
Kim, Kijeong
Ha, Jonglin
Chung, Yong-Rak
author_sort Ji, Eun-Sang
collection PubMed
description Huntington’s disease is a chronic neurodegenerative disorder inherited in an autosomal dominant fashion, and characterized as involuntary movement. Quinolinic acid has been used to produce an animal model of Huntington’s disease. In the present study, the effect of treadmill exercise on spatial-learning ability and motor coordination focusing on the apoptosis in the hippocampus was investigated using quinolinic acid-induced Huntington’s disease rats. Huntington’s disease was induced by unilateral intrastriatal injection of quinolinic acid (2 μL of 100 nmol) using stereotaxic instrument. The rats in the treadmill exercise groups were subjected to run on a treadmill for 30 min once a day during 14 days. Spatial learning ability and motor coordination were determined by radial 8-arm maze test and rota-rod test. Immunohistochemistry for caspase-3 and western blot for Bax and Bcl-2 were also conducted for the detection of apoptosis. In the present results, spatial learning ability and motor coordination were deteriorated by intrastriatal injection of quinolinic acid. In contrast, treadmill exercise exerted ameliorating effect on quinolinic acid-induced deterioration of spatial learning ability and motor coordination. Bcl-2 expression in the hippocampus was de-creased and expressions of casepase-3 and Bax in the hippocampus were increased in the quinolinic acid-induced Huntington’s disease rats. Treadmill exercise increased Bcl-2 expression and decreased expressions of casepase-3 and Bax in the Huntington’s disease rats. The present results showed that treadmill exercise might ameliorate quinolinic acid-induced loss of spatial learning ability and motor coordination by suppressing apoptosis in the hippocampus.
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spelling pubmed-44924222015-07-13 Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington’s disease rats Ji, Eun-Sang Kim, You-Mi Shin, Mal-Soon Kim, Chang-Ju Lee, Kwang-Sik Kim, Kijeong Ha, Jonglin Chung, Yong-Rak J Exerc Rehabil Original Article Huntington’s disease is a chronic neurodegenerative disorder inherited in an autosomal dominant fashion, and characterized as involuntary movement. Quinolinic acid has been used to produce an animal model of Huntington’s disease. In the present study, the effect of treadmill exercise on spatial-learning ability and motor coordination focusing on the apoptosis in the hippocampus was investigated using quinolinic acid-induced Huntington’s disease rats. Huntington’s disease was induced by unilateral intrastriatal injection of quinolinic acid (2 μL of 100 nmol) using stereotaxic instrument. The rats in the treadmill exercise groups were subjected to run on a treadmill for 30 min once a day during 14 days. Spatial learning ability and motor coordination were determined by radial 8-arm maze test and rota-rod test. Immunohistochemistry for caspase-3 and western blot for Bax and Bcl-2 were also conducted for the detection of apoptosis. In the present results, spatial learning ability and motor coordination were deteriorated by intrastriatal injection of quinolinic acid. In contrast, treadmill exercise exerted ameliorating effect on quinolinic acid-induced deterioration of spatial learning ability and motor coordination. Bcl-2 expression in the hippocampus was de-creased and expressions of casepase-3 and Bax in the hippocampus were increased in the quinolinic acid-induced Huntington’s disease rats. Treadmill exercise increased Bcl-2 expression and decreased expressions of casepase-3 and Bax in the Huntington’s disease rats. The present results showed that treadmill exercise might ameliorate quinolinic acid-induced loss of spatial learning ability and motor coordination by suppressing apoptosis in the hippocampus. Korean Society of Exercise Rehabilitation 2015-06-30 /pmc/articles/PMC4492422/ /pubmed/26171378 http://dx.doi.org/10.12965/jer.150212 Text en Copyright © 2015 Korean Society of Exercise Rehabilitation This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ji, Eun-Sang
Kim, You-Mi
Shin, Mal-Soon
Kim, Chang-Ju
Lee, Kwang-Sik
Kim, Kijeong
Ha, Jonglin
Chung, Yong-Rak
Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington’s disease rats
title Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington’s disease rats
title_full Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington’s disease rats
title_fullStr Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington’s disease rats
title_full_unstemmed Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington’s disease rats
title_short Treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in Huntington’s disease rats
title_sort treadmill exercise enhances spatial learning ability through suppressing hippocampal apoptosis in huntington’s disease rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492422/
https://www.ncbi.nlm.nih.gov/pubmed/26171378
http://dx.doi.org/10.12965/jer.150212
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