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Renal cell carcinoma: histological classification and correlation with imaging findings
Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its his...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Colégio Brasileiro de Radiologia e Diagnóstico por
Imagem
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492569/ https://www.ncbi.nlm.nih.gov/pubmed/26185343 http://dx.doi.org/10.1590/0100-3984.2013.1927 |
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author | Muglia, Valdair F. Prando, Adilson |
author_facet | Muglia, Valdair F. Prando, Adilson |
author_sort | Muglia, Valdair F. |
collection | PubMed |
description | Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes. Imaging methods play an outstanding role in the diagnosis, staging and follow-up of RCC. Clear cell, papillary and chromophobe are the most common histological subtypes of RCC, and their preoperative radiological characterization, either followed or not by confirmatory percutaneous biopsy, may be particularly useful in cases of poor surgical condition, metastatic disease, central mass in a solitary kidney, and in patients eligible for molecular targeted therapy. New strategies recently developed for treating renal cancer, such as cryo and radiofrequency ablation, molecularly targeted therapy and active surveillance also require appropriate preoperative characterization of renal masses. Less common histological types, although sharing nonspecific imaging features, may be suspected on the basis of clinical and epidemiological data. The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes. |
format | Online Article Text |
id | pubmed-4492569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Colégio Brasileiro de Radiologia e Diagnóstico por
Imagem |
record_format | MEDLINE/PubMed |
spelling | pubmed-44925692015-07-16 Renal cell carcinoma: histological classification and correlation with imaging findings Muglia, Valdair F. Prando, Adilson Radiol Bras Review Articles Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes. Imaging methods play an outstanding role in the diagnosis, staging and follow-up of RCC. Clear cell, papillary and chromophobe are the most common histological subtypes of RCC, and their preoperative radiological characterization, either followed or not by confirmatory percutaneous biopsy, may be particularly useful in cases of poor surgical condition, metastatic disease, central mass in a solitary kidney, and in patients eligible for molecular targeted therapy. New strategies recently developed for treating renal cancer, such as cryo and radiofrequency ablation, molecularly targeted therapy and active surveillance also require appropriate preoperative characterization of renal masses. Less common histological types, although sharing nonspecific imaging features, may be suspected on the basis of clinical and epidemiological data. The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes. Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 2015 /pmc/articles/PMC4492569/ /pubmed/26185343 http://dx.doi.org/10.1590/0100-3984.2013.1927 Text en © Colégio Brasileiro de Radiologia e Diagnóstico por Imagem http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Muglia, Valdair F. Prando, Adilson Renal cell carcinoma: histological classification and correlation with imaging findings |
title | Renal cell carcinoma: histological classification and correlation with
imaging findings |
title_full | Renal cell carcinoma: histological classification and correlation with
imaging findings |
title_fullStr | Renal cell carcinoma: histological classification and correlation with
imaging findings |
title_full_unstemmed | Renal cell carcinoma: histological classification and correlation with
imaging findings |
title_short | Renal cell carcinoma: histological classification and correlation with
imaging findings |
title_sort | renal cell carcinoma: histological classification and correlation with
imaging findings |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492569/ https://www.ncbi.nlm.nih.gov/pubmed/26185343 http://dx.doi.org/10.1590/0100-3984.2013.1927 |
work_keys_str_mv | AT mugliavaldairf renalcellcarcinomahistologicalclassificationandcorrelationwithimagingfindings AT prandoadilson renalcellcarcinomahistologicalclassificationandcorrelationwithimagingfindings |