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Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening

Cholesterol plays an important role in living cells. However, a very high level of cholesterol may lead to atherosclerosis. HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase is the key enzyme in the cholesterol biosynthesis pathway, and the statin-like drugs are inhibitors of human HMG-CoA r...

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Detalles Bibliográficos
Autores principales:	Lin, Shih-Hung, Huang, Kao-Jean, Weng, Ching-Feng, Shiuan, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492635/ https://www.ncbi.nlm.nih.gov/pubmed/26170618 http://dx.doi.org/10.2147/DDDT.S84641

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