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Predictors of atrial fibrillation recurrence after cryoballoon ablation

OBJECTIVE: Cryoballoon ablation (CA) is a safe and efficient method for pulmonary vein isolation in the treatment of paroxysmal atrial fibrillation (AF). There are conflicting results about the predictors of AF recurrence. The aim of this study is to evaluate the role of hematological indices to pre...

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Autores principales: Aksu, Tolga, Baysal, Erkan, Guler, Tümer Erdem, Golcuk, Sukriye Ebru, Erden, İsmail, Ozcan, Kazim Serhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492636/
https://www.ncbi.nlm.nih.gov/pubmed/26170730
http://dx.doi.org/10.2147/JBM.S81551
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author Aksu, Tolga
Baysal, Erkan
Guler, Tümer Erdem
Golcuk, Sukriye Ebru
Erden, İsmail
Ozcan, Kazim Serhan
author_facet Aksu, Tolga
Baysal, Erkan
Guler, Tümer Erdem
Golcuk, Sukriye Ebru
Erden, İsmail
Ozcan, Kazim Serhan
author_sort Aksu, Tolga
collection PubMed
description OBJECTIVE: Cryoballoon ablation (CA) is a safe and efficient method for pulmonary vein isolation in the treatment of paroxysmal atrial fibrillation (AF). There are conflicting results about the predictors of AF recurrence. The aim of this study is to evaluate the role of hematological indices to predict AF recurrence after CA. METHODS: A total of 49 patients (mean age 58.3±12.2 years, 51.02% female) with symptomatic paroxysmal AF underwent CA procedure. One hundred and sixty-eight pulmonary veins were used for pulmonary vein isolation with the second-generation cryoballoon. The hematological samples were obtained before and 24 hours after ablation. RESULTS: At a mean follow-up of 10.2±2.4 months, the probability of being arrhythmia-free after a single procedure was 86%. Patients with AF recurrence had higher red cell distribution width levels (16.10%±1.44% vs 14.87%±0.48%, P=0.035). The neutrophil/lymphocyte ratio, erythrocyte sedimentation rate, and C-reactive protein levels were detected in the patients with or without recurrence. Left atrial diameter (46.28±4.30 mm vs 41.02±4.10 mm, P=0.002), duration of AF (6.71±4.57 years vs 3.59±1.72 years, P=0.003), and age (65.01±15.39 years vs 54.29±11.32 years, P=0.033) were the other independent predictors of clinical recurrence after CA. Multiple regression analysis revealed that left atrial diameter was the only independent predictor for AF recurrence (P=0.012). CONCLUSION: In this study of patients with paroxysmal AF undergoing cryoablation, increased preablation red cell distribution width levels, and not C-reactive protein or erythrocyte sedimentation rate, was associated with a higher rate of AF recurrence. Our results support the role of a preablation, proinflammatory, and pro-oxidant environment in the development of AF recurrence after ablation therapy but suggest that other factors are also important.
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spelling pubmed-44926362015-07-13 Predictors of atrial fibrillation recurrence after cryoballoon ablation Aksu, Tolga Baysal, Erkan Guler, Tümer Erdem Golcuk, Sukriye Ebru Erden, İsmail Ozcan, Kazim Serhan J Blood Med Original Research OBJECTIVE: Cryoballoon ablation (CA) is a safe and efficient method for pulmonary vein isolation in the treatment of paroxysmal atrial fibrillation (AF). There are conflicting results about the predictors of AF recurrence. The aim of this study is to evaluate the role of hematological indices to predict AF recurrence after CA. METHODS: A total of 49 patients (mean age 58.3±12.2 years, 51.02% female) with symptomatic paroxysmal AF underwent CA procedure. One hundred and sixty-eight pulmonary veins were used for pulmonary vein isolation with the second-generation cryoballoon. The hematological samples were obtained before and 24 hours after ablation. RESULTS: At a mean follow-up of 10.2±2.4 months, the probability of being arrhythmia-free after a single procedure was 86%. Patients with AF recurrence had higher red cell distribution width levels (16.10%±1.44% vs 14.87%±0.48%, P=0.035). The neutrophil/lymphocyte ratio, erythrocyte sedimentation rate, and C-reactive protein levels were detected in the patients with or without recurrence. Left atrial diameter (46.28±4.30 mm vs 41.02±4.10 mm, P=0.002), duration of AF (6.71±4.57 years vs 3.59±1.72 years, P=0.003), and age (65.01±15.39 years vs 54.29±11.32 years, P=0.033) were the other independent predictors of clinical recurrence after CA. Multiple regression analysis revealed that left atrial diameter was the only independent predictor for AF recurrence (P=0.012). CONCLUSION: In this study of patients with paroxysmal AF undergoing cryoablation, increased preablation red cell distribution width levels, and not C-reactive protein or erythrocyte sedimentation rate, was associated with a higher rate of AF recurrence. Our results support the role of a preablation, proinflammatory, and pro-oxidant environment in the development of AF recurrence after ablation therapy but suggest that other factors are also important. Dove Medical Press 2015-06-29 /pmc/articles/PMC4492636/ /pubmed/26170730 http://dx.doi.org/10.2147/JBM.S81551 Text en © 2015 Aksu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Aksu, Tolga
Baysal, Erkan
Guler, Tümer Erdem
Golcuk, Sukriye Ebru
Erden, İsmail
Ozcan, Kazim Serhan
Predictors of atrial fibrillation recurrence after cryoballoon ablation
title Predictors of atrial fibrillation recurrence after cryoballoon ablation
title_full Predictors of atrial fibrillation recurrence after cryoballoon ablation
title_fullStr Predictors of atrial fibrillation recurrence after cryoballoon ablation
title_full_unstemmed Predictors of atrial fibrillation recurrence after cryoballoon ablation
title_short Predictors of atrial fibrillation recurrence after cryoballoon ablation
title_sort predictors of atrial fibrillation recurrence after cryoballoon ablation
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492636/
https://www.ncbi.nlm.nih.gov/pubmed/26170730
http://dx.doi.org/10.2147/JBM.S81551
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