Transthyretin Amyloidosis: Chaperone Concentration Changes and Increased Proteolysis in the Pathway to Disease

Transthyretin amyloidosis is a conformational pathology characterized by the extracellular formation of amyloid deposits and the progressive impairment of the peripheral nervous system. Point mutations in this tetrameric plasma protein decrease its stability and are linked to disease onset and progr...

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Detalles Bibliográficos
Autores principales: da Costa, Gonçalo, Ribeiro-Silva, Cristina, Ribeiro, Raquel, Gilberto, Samuel, Gomes, Ricardo A., Ferreira, António, Mateus, Élia, Barroso, Eduardo, Coelho, Ana V., Freire, Ana Ponces, Cordeiro, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492746/
https://www.ncbi.nlm.nih.gov/pubmed/26147092
http://dx.doi.org/10.1371/journal.pone.0125392

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