Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches

New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and m...

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Detalles Bibliográficos
Autores principales: Al-Amiery, Ahmed A., Al-Majedy, Yasameen K., Kadhum, Abdul Amir H., Mohamad, Abu Bakar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492988/
https://www.ncbi.nlm.nih.gov/pubmed/26147722
http://dx.doi.org/10.1371/journal.pone.0132175
Descripción
Sumario:New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS). In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C. Our results reveal that these compounds exhibit excellent radical scavenging activities.

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