Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches

New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and m...

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Detalles Bibliográficos
Autores principales: Al-Amiery, Ahmed A., Al-Majedy, Yasameen K., Kadhum, Abdul Amir H., Mohamad, Abu Bakar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492988/
https://www.ncbi.nlm.nih.gov/pubmed/26147722
http://dx.doi.org/10.1371/journal.pone.0132175
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author Al-Amiery, Ahmed A.
Al-Majedy, Yasameen K.
Kadhum, Abdul Amir H.
Mohamad, Abu Bakar
author_facet Al-Amiery, Ahmed A.
Al-Majedy, Yasameen K.
Kadhum, Abdul Amir H.
Mohamad, Abu Bakar
author_sort Al-Amiery, Ahmed A.
collection PubMed
description New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS). In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C. Our results reveal that these compounds exhibit excellent radical scavenging activities.
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spelling pubmed-44929882015-07-15 Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches Al-Amiery, Ahmed A. Al-Majedy, Yasameen K. Kadhum, Abdul Amir H. Mohamad, Abu Bakar PLoS One Research Article New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS). In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C. Our results reveal that these compounds exhibit excellent radical scavenging activities. Public Library of Science 2015-07-06 /pmc/articles/PMC4492988/ /pubmed/26147722 http://dx.doi.org/10.1371/journal.pone.0132175 Text en © 2015 Al-Amiery et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Al-Amiery, Ahmed A.
Al-Majedy, Yasameen K.
Kadhum, Abdul Amir H.
Mohamad, Abu Bakar
Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches
title Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches
title_full Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches
title_fullStr Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches
title_full_unstemmed Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches
title_short Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches
title_sort hydrogen peroxide scavenging activity of novel coumarins synthesized using different approaches
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492988/
https://www.ncbi.nlm.nih.gov/pubmed/26147722
http://dx.doi.org/10.1371/journal.pone.0132175
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AT mohamadabubakar hydrogenperoxidescavengingactivityofnovelcoumarinssynthesizedusingdifferentapproaches

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