The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia

Histone methyltransferases are epigenetic regulators that modify key lysine and arginine residues on histones and are believed to play an important role in cancer development and maintenance. These epigenetic modifications are potentially reversible and as a result this class of enzymes has drawn gr...

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Detalles Bibliográficos
Autores principales: Pappano, William N., Guo, Jun, He, Yupeng, Ferguson, Debra, Jagadeeswaran, Sujatha, Osterling, Donald J., Gao, Wenqing, Spence, Julie K., Pliushchev, Marina, Sweis, Ramzi F., Buchanan, Fritz G., Michaelides, Michael R., Shoemaker, Alexander R., Tse, Chris, Chiang, Gary G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492996/
https://www.ncbi.nlm.nih.gov/pubmed/26147105
http://dx.doi.org/10.1371/journal.pone.0131716

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