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A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization

CD4 interactions with class II major histocompatibility complex (MHC) molecules are essential for CD4(+) T cell development, activation, and effector functions. While its association with p56(lck) (Lck), a Src kinase, is important for these functions CD4 also has an Lck-independent role in TCR signa...

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Detalles Bibliográficos
Autores principales:	Parrish, Heather L., Glassman, Caleb R., Keenen, Madeline M., Deshpande, Neha R., Bronnimann, Matthew P., Kuhns, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493003/ https://www.ncbi.nlm.nih.gov/pubmed/26147390 http://dx.doi.org/10.1371/journal.pone.0132333

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