Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency

INTRODUCTION: The pyruvate dehydrogenase (PDH) complex is localized in the mitochondrial matrix catalyzing the irreversible decarboxylation of pyruvate to acetyl-CoA and NADH. For proper complex regulation the E1-α subunit functions as an on/off switch regulated by phosphorylation/dephosphorylation....

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Detalles Bibliográficos
Autores principales: Rodrigues, Ana Sofia, Correia, Marcelo, Gomes, Andreia, Pereira, Sandro L., Perestrelo, Tânia, Sousa, Maria Inês, Ramalho-Santos, João
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493017/
https://www.ncbi.nlm.nih.gov/pubmed/26147621
http://dx.doi.org/10.1371/journal.pone.0131663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493017/
https://www.ncbi.nlm.nih.gov/pubmed/26147621
http://dx.doi.org/10.1371/journal.pone.0131663

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