Cargando…

Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency

INTRODUCTION: The pyruvate dehydrogenase (PDH) complex is localized in the mitochondrial matrix catalyzing the irreversible decarboxylation of pyruvate to acetyl-CoA and NADH. For proper complex regulation the E1-α subunit functions as an on/off switch regulated by phosphorylation/dephosphorylation....

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodrigues, Ana Sofia, Correia, Marcelo, Gomes, Andreia, Pereira, Sandro L., Perestrelo, Tânia, Sousa, Maria Inês, Ramalho-Santos, João
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493017/ https://www.ncbi.nlm.nih.gov/pubmed/26147621 http://dx.doi.org/10.1371/journal.pone.0131663

Ejemplares similares

Effects of DMSO on the Pluripotency of Cultured Mouse Embryonic Stem Cells (mESCs)
por: Sousa, Maria Inês, et al.
Publicado: (2020)

Differentiate or Die: 3-Bromopyruvate and Pluripotency in Mouse Embryonic Stem Cells
por: Rodrigues, Ana Sofia, et al.
Publicado: (2015)

Noncanonical function of DGCR8 controls mESC exit from pluripotency
por: Cirera-Salinas, Daniel, et al.
Publicado: (2017)

Comparison Between Dichloroacetate and Phenylbutyrate Treatment for Pyruvate Dehydrogenase Deficiency
por: Karissa, Patricia, et al.
Publicado: (2022)

Oncostatin M Maintains Naïve Pluripotency of mESCs by Tetraploid Embryo Complementation (TEC) Assay
por: Ye, Xiaoying, et al.
Publicado: (2021)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
por: Ferrarini, Mariana Galvão, et al.
Publicado: (2021)

Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software
por: Perestrelo, Tânia, et al.
Publicado: (2018)

Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software
por: Perestrelo, Tânia, et al.
Publicado: (2017)

Regulation of Muscle Pyruvate Dehydrogenase Complex in Insulin Resistance: Effects of Exercise and Dichloroacetate
por: Constantin-Teodosiu, Dumitru
Publicado: (2013)

Pyruvate Dehydrogenase Kinase Inhibition by Dichloroacetate in Melanoma Cells Unveils Metabolic Vulnerabilities
por: Tiersma, Jiske F., et al.
Publicado: (2022)

A Model-Based Analysis of Culture-Dependent Phenotypes of mESCs
por: Herberg, Maria, et al.
Publicado: (2014)

A method for stabilising the XX karyotype in female mESC cultures
por: Keniry, Andrew, et al.
Publicado: (2022)

Icaritin enhances mESC self-renewal through upregulating core pluripotency transcription factors mediated by ERα
por: Tsang, Wing Pui, et al.
Publicado: (2017)

Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate
por: Ferriero, Rosa, et al.
Publicado: (2015)

Zebularine regulates early stages of mESC differentiation: effect on cardiac commitment
por: Horrillo, A, et al.
Publicado: (2013)

Differential contribution of p300 and CBP to regulatory element acetylation in mESCs
por: Martire, Sara, et al.
Publicado: (2020)

Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch
por: Kaji, Deepak A., et al.
Publicado: (2021)

EdU induces DNA damage response and cell death in mESC in culture
por: Kohlmeier, Fanni, et al.
Publicado: (2013)

Global and precise identification of functional miRNA targets in mESCs by integrative analysis
por: Schaefer, Moritz, et al.
Publicado: (2022)

Loss of Dip2b leads to abnormal neural differentiation from mESCs
por: Yao, Mingze, et al.
Publicado: (2023)

MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs
por: Eckersley-Maslin, Mélanie A., et al.
Publicado: (2016)

Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, ameliorates type 2 diabetes via reduced gluconeogenesis
por: Katayama, Yuko, et al.
Publicado: (2022)

Transplantation of miPSC/mESC-derived retinal ganglion cells into healthy and glaucomatous retinas
por: Oswald, Julia, et al.
Publicado: (2021)

A Fiber Alginate Co-culture Platform for the Differentiation of mESC and Modeling of the Neural Tube
por: Fannon, Orla M., et al.
Publicado: (2021)

Data on the potential impact of food supplements on the growth of mouse embryonic stem cells
por: Correia, Marcelo, et al.
Publicado: (2016)

Cobalt-conjugated carbon quantum dots for in vivo monitoring of the pyruvate dehydrogenase kinase inhibitor drug dichloroacetic acid
por: Raut, Jiko, et al.
Publicado: (2022)

Imaging, quantification and visualization of spatio-temporal patterning in mESC colonies under different culture conditions
por: Scherf, N., et al.
Publicado: (2012)

N (6)-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential
por: Yang, Dandan, et al.
Publicado: (2018)

The PWWP2A Histone Deacetylase Complex Represses Intragenic Spurious Transcription Initiation in mESCs
por: Wei, Guifeng, et al.
Publicado: (2020)

Distribution and Afferent Effects of Transplanted mESCs on Cochlea in Acute and Chronic Neural Hearing Loss Models
por: Chang, So-Young, et al.
Publicado: (2021)

CRISPR-Mediated Knockout of Long 3′ UTR mRNA Isoforms in mESC-Derived Neurons
por: Bae, Bongmin, et al.
Publicado: (2021)

Pyruvate Dehydrogenase Kinase Inhibitor Dichloroacetate Improves Host Control of Salmonella enterica Serovar Typhimurium Infection in Human Macrophages
por: van Doorn, Cassandra L. R., et al.
Publicado: (2021)

Suppression of Pyruvate Dehydrogenase Kinase by Dichloroacetate in Cancer and Skeletal Muscle Cells Is Isoform Specific and Partially Independent of HIF-1α
por: Škorja Milić, Nives, et al.
Publicado: (2021)

Assessing genome-wide dynamic changes in enhancer activity during early mESC differentiation by FAIRE-STARR-seq
por: Glaser, Laura V, et al.
Publicado: (2021)

Generation of an mESC model with a human hemophilia B nonsense mutation via CRISPR/Cas9 technology
por: Ma, Yanchun, et al.
Publicado: (2022)

Genome-wide 5-hydroxymethylcytosine (5hmC) reassigned in Pten-depleted mESCs along neural differentiation
por: Wang, Zhangting, et al.
Publicado: (2022)

Combined Treatment of Dichloroacetic Acid and Pyruvate Increased Neuronal Survival after Seizure
por: Lee, Song Hee, et al.
Publicado: (2022)

Single cell studies of mouse embryonic stem cell (mESC) differentiation by electrical impedance measurements in a microfluidic device
por: Zhou, Ying, et al.
Publicado: (2016)

The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation
por: Zhang, Jinglong, et al.
Publicado: (2018)

Substrates of the m(6)A demethylase FTO: FTO-LINE1 RNA axis regulates chromatin state in mESCs
por: Sommerkamp, Pia
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_57umg8m218pdgq1sh357k208s9